- 2,4,6-Trifluoropyrimidine. Reactions with nitrogen nucleophiles
-
In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2,4,6-trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2,4,6-trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2-substitution with ammonia and ethanolamine while aniline gave the 4-substituted derivative as the preferred product.
- Delia, Thomas J.,Anderson, Dennis P.,Schomaker, Jennifer M.
-
p. 991 - 993
(2007/10/03)
-
- MECHANISMS FOR REACTIONS OF HALOGENATED COMPOUNDS. PART 6. INVESTIGATIONS INTO THE ACTIVATING EFFECT OF ORTHO-FLUORINE IN NUCLEOPHILIC AROMATIC SUBSTITUTION
-
Separate activating effects for ortho- and meta- fluorine, on nucleophilic aromatic substitution, are determinated for pyrimidine and pyridine systems.Comparisons confirm the importance of ion-dipole interactions for activation by ortho-fluorine.The effects of ortho-fluorine on anionic ?-complexes are also discussed.
- Chambers, Richard D.,Seabury, Mark J.,Williams, D. Lyn H.,Hughes, Nigel
-
p. 255 - 258
(2007/10/02)
-