675-11-6Relevant articles and documents
2,4,6-Trifluoropyrimidine. Reactions with nitrogen nucleophiles
Delia, Thomas J.,Anderson, Dennis P.,Schomaker, Jennifer M.
, p. 991 - 993 (2007/10/03)
In a continuation of our studies involving the nucleophilic displacement of one of the chlorines from 2,4,6-trichloropyrimidine, we now report the initial displacement of one of the fluorine atoms from 2,4,6-trifluoropyrimidine using both aliphatic and aromatic amines. The monosubstitution products favor 2-substitution with ammonia and ethanolamine while aniline gave the 4-substituted derivative as the preferred product.