- Two-step synthesis method of C15 alcohol for preparing canthaxanthin
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The invention discloses a two-step synthesis method of C15 alcohol for preparing canthaxanthin. The method comprises the following steps: reacting 4-oxo-beta-violonone serving as a raw material with an ethynyl Grignard reagent at a low temperature in the presence of an organic solvent, and performing hydrolyzing with protonic acid to obtain 3-[3-hydroxy-3-methyl-pent-1-alkyn-4-alkenyl]-2,4, 4-trimethyl-cyclohexane-2-ene-1-ketone; and in the presence of a solvent, carrying out a catalytic hydrogenation reaction by using a Lindlar catalyst to obtain 3-[3-hydroxy-3-methyl-pent-1,4-dienyl]-2,4,4-trimethyl-cyclohex-2-ene-1-ketone. The preparation method disclosed by the invention has the advantages of low raw material price, few reaction steps, mild reaction conditions, environmental friendliness, convenience in operation, high reaction yield, easiness in industrialization and the like.
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Paragraph 0030; 0036-0038; 0043-0044; 0049-0050; 0055; ...
(2021/09/26)
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- PROCESS FOR THE PREPARATION OF OXOVINYLIONOL AND ITS O-PROTECTED DERIVATIVES
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The present invention relates to the preparation of oxovinylionol and its O-protected derivatives of the formula I in which R is hydrogen or an OH protecting group, for example a group Si(Ra)3, by reacting a compound of the general formula II in which R has the meanings given above for formula I, i.e. β-vinyl ionol (formula II, R=hydrogen) or an O-protected derivative thereof (formula II, R═OH protecting group) with an oxidant in the presence of at least one transition metal, where the oxidant comprises at least one oxygen-containing compound which is selected from among hydrogen peroxide and organic hydroperoxides.
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Paragraph 0118
(2013/05/21)
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