67777-14-4Relevant articles and documents
Two-step synthesis method of C15 alcohol for preparing canthaxanthin
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Paragraph 0030; 0036-0038; 0043-0044; 0049-0050; 0055; ..., (2021/09/26)
The invention discloses a two-step synthesis method of C15 alcohol for preparing canthaxanthin. The method comprises the following steps: reacting 4-oxo-beta-violonone serving as a raw material with an ethynyl Grignard reagent at a low temperature in the presence of an organic solvent, and performing hydrolyzing with protonic acid to obtain 3-[3-hydroxy-3-methyl-pent-1-alkyn-4-alkenyl]-2,4, 4-trimethyl-cyclohexane-2-ene-1-ketone; and in the presence of a solvent, carrying out a catalytic hydrogenation reaction by using a Lindlar catalyst to obtain 3-[3-hydroxy-3-methyl-pent-1,4-dienyl]-2,4,4-trimethyl-cyclohex-2-ene-1-ketone. The preparation method disclosed by the invention has the advantages of low raw material price, few reaction steps, mild reaction conditions, environmental friendliness, convenience in operation, high reaction yield, easiness in industrialization and the like.