Hexafluoroisopropanol-Mediated Redox-Neutral α-C(sp3)-H Functionalization of Cyclic Amines via Hydride Transfer
Hexafluoroisopropanol has been demonstrated as the versatile promoter for redox-neutral α-C(sp3)-H functionalization of cyclic amines via the cascade [1,5]-hydride transfer/cyclization strategy. A wide range of cyclic amines are functionalized
Spirocyclic Tetramates by Sequential Knoevenagel and [1,5]-Prototropic Shift
Highly functionalized spirocyclic tetramates were prepared via a sequential Knoevenagel reaction and [1,5]-prototropic shift (T-reaction) of bicyclic tetramates. While these compounds isomerize in solution, stable analogues can be prepared via an appropri
Josa-Culleré, Laia,Hirst, Michael G.,Lockett, Jonathan P.,Thompson, Amber L.,Moloney, Mark G.
p. 9671 - 9683
(2019/09/06)
Method for synthetizing PNU-286607 and analogues of PNU-286607
The invention relates to a method for synthetizing PNU 286607 and analogues of PNU-286607. The method is concretely characterized in that 2-fluorine-5-nitrobenzaldehyde and secondary amine react underthe 20-80 DEG C water phase or ethyl alcohol phase cond
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Paragraph 0041-0046; 0137
(2018/04/03)
Construction of the tetrahydroquinoline spiro skeleton: Via cascade [1,5]-hydride transfer-involved C(sp3)-H functionalization "on water"
The pharmaceutically important tetrahydroquinoline spiro compounds were efficiently constructed via cascade SNAr/Knoevenagel condensation/[1,5]-hydride transfer/cyclization on water, featuring high atom-economy and step-economy. This water-base
PYRIMIDOPYRIMIDINONES USEFUL AS WEE-1 KINASE INHIBITORS
The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
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Paragraph 293; 294
(2015/07/07)
CHEMICAL COMPOUNDS
In one aspect, the present invention relates to compounds of Formula (I): to pharmaceutically acceptable sa lts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation.
The invention includes tetrahydroquinoline and related compounds of formula (I), and pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
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Page 34
(2008/06/13)
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