- Direct Carboxylation of Electron-Rich Heteroarenes Promoted by LiO-tBu with CsF and [18]Crown-6
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We herein demonstrate that the combination of LiO-tBu, CsF, and [18]crown-6 efficiently promotes the direct C?H carboxylation of electron-rich heteroarenes (benzothiophene, thiophene, benzofuran, and furan derivatives). A variety of functional groups, including methyl, methoxy, halo, cyano, amide, and keto moieties, are compatible with this system. The reaction proceeds via the formation of a tert-butyl carbonate species.
- Shigeno, Masanori,Hanasaka, Kazuya,Sasaki, Keita,Nozawa-Kumada, Kanako,Kondo, Yoshinori
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supporting information
p. 3235 - 3239
(2019/02/13)
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- Hedgehog signal pathway inhibitor
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The invention provides a Hedgehog signal pathway inhibitor as well as stereoisomers, tautomers, hydrates, solvates or pharmaceutically acceptable salts thereof, and the structural formula of the inhibitor is as shown in a formula (I). The invention further provides a preparation method and application of a compound. The compound provided by the invention is novel in structure; a signal transduction pathway adjusted by Hedgehog protein, Ptch, Gli and/or Smo can be adjusted through the compound of the formula I.
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Paragraph 0103; 0170; 0171; 0172
(2017/06/20)
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- Microwave assisted synthesis of 5-arylthiophene-2-carboxylates
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A simple and rapid method for the synthesis of 5-Aryl-thiophene-2- carboxylates 3 has been developed by the condensation of β-chlorovinyl aldehydes 1 with mercaptoacetic acid esters 2 under microwave irradiation conditions.
- Jagath Reddy,Latha,Sailaja,Pallavi,Srinivasa Rao
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p. 411 - 414
(2007/10/03)
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