- Facile synthesis of Cu3(BTC)2/cellulose acetate mixed matrix membranes and their catalytic applications in continuous flow process
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Metal-organic framework (MOF)-based mixed matrix membranes (MMMs) were fabricated by a combination of Cu3(BTC)2 MOF and polymer cellulose acetate. The cellulose acetate in the MMMs served as the matrix and the Cu3(BTC)2 MOF as the filler. The as-synthesized MMMs were utilized as a heterogeneous catalyst for aldehyde acetalization. The characterization techniques indicated that the Cu3(BTC)2 crystals were uniformly dispersed in the MMMs. The BET surface area of the Cu3(BTC)2-based MMM was measured to be 459 m2 g-1 at 60 wt% Cu3(BTC)2 loading. Furthermore, the MMMs served as an excellent catalyst under our continuous flow catalytic reaction conditions. The optimal catalytic result of benzaldehyde yield reached 94% with 60 wt% Cu3(BTC)2 loading of the MMMs at room temperature and the benzaldehyde diethyl acetal reached 0.59 mmol min-1 gCu-BTC-1.
- Hou, Junying,Luan, Yi,Huang, Xiubing,Gao, Hongyi,Yang, Mu,Lu, Yunfeng
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p. 9123 - 9129
(2017/08/29)
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- ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS
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The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer's disease, Parkinson's disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation
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Paragraph 0554
(2017/10/13)
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- Use of Catalytic Static Mixers for Continuous Flow Gas-Liquid and Transfer Hydrogenations in Organic Synthesis
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Catalytic static mixers were used for the continuous flow hydrogenation of alkenes, alkynes, carbonyls, nitro- and diazo-compounds, nitriles, imines, and halides. This technique relies on tubular reactors fitted with 3D printed static mixers which are coated with a catalytic metal layer, either Pd or Ni. Additive manufacturing of the metal mixer scaffold results in maximum design flexibility and is compatible with deposition methods such as metal cold spraying which allow for mass production and linear process scale up. High to full conversion was achieved for the majority of substrates, demonstrating the flexibility and versatility of the catalytic static mixer technology. In the example of an alkyne reduction, the selectivity of the flow reactor could be directed to either yield an alkene or alkane product by simply changing the reactor pressure.
- Hornung, Christian H.,Nguyen, Xuan,Carafa, Antony,Gardiner, James,Urban, Andrew,Fraser, Darren,Horne, Mike D.,Gunasegaram, Dayalan R.,Tsanaktsidis, John
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supporting information
p. 1311 - 1319
(2017/09/23)
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- Kinetic resolution in asymmetric epoxidation using iminium salt catalysis
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The first reported examples of kinetic resolution in epoxidation reactions using iminium salt catalysis are described, providing up to 99% ee in the epoxidation of racemic cis-chromenes.
- Bulman Page, Philip C.,Appleby, Louise F.,Chan, Yohan,Day, David P.,Buckley, Benjamin R.,Slawin, Alexandra M. Z.,Allin, Steven M.,McKenzie, Michael J.
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p. 8074 - 8082
(2013/09/12)
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- Ferric hydroxide supported gold subnano clusters or quantum dots: Enhanced catalytic performance in chemoselective hydrogenation
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An attempt to prepare ferric hydroxide supported Au subnano clusters via modified co-precipitation without any calcination was made. High resolution transmission electron microscopy (HRTEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) have been employed to study the structure and chemical states of these catalysts. No Au species could be observed in the HRTEM image nor from the XRD pattern, suggesting that the sizes of the Au species in and on the ferric hydroxide support were less than or around 1 nm. Chemoselective hydrogenation of aromatic nitro compounds and α,β-unsaturated aldehydes was selected as a probe reaction to examine the catalytic properties of this catalyst. Under the same reaction conditions, such as 100 °C and 1 MPa H2 in the hydrogenation of aromatic nitro compounds, a 96-99% conversion (except for 4-nitrobenzonitrile) with 99% selectivity was obtained over the ferric hydroxide supported Au catalyst, and the TOF values were 2-6 times higher than that of the corresponding ferric oxide supported catalyst with 3-5 nm size Au particles. For further evaluation of this Au catalyst in the hydrogenation of citral and cinnamaldehyde, selectivity towards unsaturated alcohols was 2-20 times higher than that of the corresponding ferric oxide Au catalyst. The Royal Society of Chemistry.
- Liu, Lequan,Qiao, Botao,Ma, Yubo,Zhang, Juan,Deng, Youquan
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p. 2542 - 2548
(2008/09/20)
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- Gallium triiodide as a highly efficient and mild catalyst for the diethyl acetalization of carbonyl compounds
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Diethyl acetals were obtained from carbonyl compounds in good to excellent yields under mild reaction conditions in the presence of triethyl orthoformate and a catalytic amount of gallium triiodide in anhydrous ethanol.
- Ding, Jin-Chang,Xu, Rong,Liu, Miao-Chang,Chen, Xi-An,Wu, Hua-Yue
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experimental part
p. 566 - 568
(2009/07/18)
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- A highly efficient and chemoselective method for acetalization of carbonyl compounds catalyzed by TiO2/SO42- solid superacid
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Various types of aldehydes and ketones could be converted to their corresponding diethyl acetals with triethylorthoformate in the presence of TiO2/SO42- solid superacid in good to excellent yield under mild reaction conditions.
- Ma, Yan-Ran,Jin, Tong-Shou,Shi, Sheng-Xun,Li, Tong-Shuang
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p. 2103 - 2108
(2007/10/03)
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- Tetrabutylammonium tribromide (TBATB) as an efficient generator of HBr for an efficient chemoselective reagent for acetalization of carbonyl compounds
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Acyclic and cyclic acetals of various carbonyl compounds were obtained in excellent yields under a mild reaction condition in the presence of trialkyl orthoformate and a catalytic amount of tetrabutylammonium tribromide (TBATB) in absolute alcohol. Chemoselective acetalization of an aldehyde in the presence of ketone, unsymmetrical acetal formation, shorter reaction times, mild reaction conditions, the stability of acid-sensitive protecting groups, high efficiencies, facile isolation of the desired products, and the catalytic nature of the reagent make the present methodology a practical alternative.
- Gopinath, Rangam,Haque, Sk. Jiaul,Patel, Bhisma K.
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p. 5842 - 5845
(2007/10/03)
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- 2,4,4,6-Tetrabromo-2,5-cyclohexadienone (TABCO) as a versatile, efficient, and chemoselective catalyst for the acetalization and transacetalization of carbonyl compounds, the preparation of acetonides from epoxides and acylals (1,1-diacetates) from aldehydes
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The efficient and chemoselective preparation of acetals and ketals from carbonyl compounds, transacetalization reactions, the conversion of epoxides to acetonides, and the preparation of acylals from aldehydes in the presence of catalytic amounts of 2,4,4,6-tetrabromo-2,5-cyclohexadienone (TABCO) are described.
- Firouzabadi, Habib,Iranpoor, Nasser,Shaterian, Hamid Reza
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p. 2195 - 2205
(2007/10/03)
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- Highly efficient and chemoselective interchange of 1,3-oxathioacetals and dithioacetals to acetals promoted by N-halosuccinimide
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Highly efficient interconversion of a range of 1,3-oxathiolanes, 1,3-dithiolanes and 1,3-dithianes to their acetals at ambient temperature using N-bromosuccinimide or N-chlorosuccinimide and different types of alcohols and diols was investigated.
- Karimi, Babak,Seradj, Hassan,Maleki, Jafar
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p. 4513 - 4516
(2007/10/03)
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- W-bromosuccinimide (NBS) as a powerful and chemoselective catalyst for acetalization of carbonyl compounds under almost neutral reaction conditions
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Highly efficient and mild acetalization of various types of carbonyl compounds was achieved using NBS under almost neutral reaction conditions. Due to the neutrality of the medium this method is especially useful for the protection of acid sensitive substrates. Thieme Stuttgart.
- Karimi, Babak
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p. 1456 - 1458
(2007/10/03)
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- Zirconium tetrachloride (ZrCl4) catalyzed highly chemoselective and efficient acetalization of carbonyl compounds
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Zirconium tetrachloride (ZrCl4) is a highly efficient and chemoselective catalyst for the acetalization, and in-situ transacetalization of carbonyl compounds under mild reaction conditions.
- Firouzabadi, Habib,Iranpoor, Nasser,Karimi, Babak
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p. 321 - 323
(2007/10/03)
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- Tungsten hexachloride (WCl6), a highly efficient and chemoselective catalyst for acetalization of carbonyl compounds
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Various types of aldehydes and ketones could be converted chemoselectively to their corresponding 1,3-dioxanes or diethyl acetals in the presence of catalytic amounts of tungsten hexachloride (WCl6) in good to excellent yields in CH2Cl2 or under neat conditions, respectively.
- Firouzabadi,Iranpoor,Karimi
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p. 2255 - 2263
(2007/10/03)
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- Solvent free protection of carbonyl group under microwave irradiation
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Protection of aldehydes and ketones as acetals or dioxolanes catalysed by PTSA or KSF clay was readily achieved from orthoformates, 1,2-ethanediol or 2,2-dimethyl-1,3-dioxolane without solvent under microwave irradiation.
- Perio, Bertrand,Dozias, Marie-Joelle,Jacquault, Patrick,Hamelin, Jack
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p. 7867 - 7870
(2007/10/03)
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- The thermally induced synthesis of N-(diethoxyphosphoryl)aldimines
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The reaction of diethyl phosphoroamidate (2) with aromatic aldehyde diethyl acetals (1) carried out at 120-160°C provides a simple, one-step preparation of N-(diethoxyphosphoryl)aldimines (3a-b). The extension of this reaction to aliphatic aldehyde diethyl acetals failed to give the expected imines.
- Zwierzak, Andrzej,Napieraj, Anna
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p. 8789 - 8794
(2007/10/03)
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- Selective Acetalization of Aldehydes with Trialkoxystibine using Allyl Bromide
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Trialkoxystibine has been found to be an effective reagent for selective acetalization of aldehydes with the aid of allyl bromide.
- Liao, Yi,Huang, Yao-Zeng,Zhu, Fang-Hua
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p. 493 - 494
(2007/10/02)
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- 1-Tributylstannyl-3,3-diethoxyprop-1-ene as a d3 Acrolein Equivalent
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1-Tributylstannyl-3,3-diethoxyprop-1-ene has proved to be a readily available β-formylvinyl anion equivalent which under mild experimental conditions gives ready access to cinnamic skeletons and 4-oxo- or 6-oxo-α,β-enals.
- Parrain, Jean-Luc,Duchene, Alain,Quintard, Jean-Paul
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p. 187 - 189
(2007/10/02)
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- A ONE POT PROCESS FOR THE OBTENTION AND REACTIONS OF GLYOXAL MONOACETAL
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A THF solution of glyoxal monoacetal 1 is obtained by SWERN oxidation of 2,2-diethoxy 1-ethanol and directly submitted to diverse nucleophilic species; The expected adducts of 1 are obtained with acceptable yields.
- Bernard, Didier,Doutheau, Alain,Gore, Jacques
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p. 1807 - 1814
(2007/10/02)
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