- Preparation and antiarthritic activity of new 1,5-diaryl-3-alkylthio-1H-1,2,4-triazoles and corresponding sulfoxides and sulfones
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A series of 1,5-diaryl-3-alkylthio-1H-1,2,4-triazoles and corresponding sulfoxides and sulfones was synthesized and evaluated as antiinflammatory agents in the rat adjuvant induced arthritis assay.Several analogues were found to be more potent than phenyl
- Szilagyi, Geza,Somorai, Tamas,Bozo, Eva,Lango, Jozsef,Nagy, Gabor,et al.
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- STRUCTURE INVESTIGATIONS ON SOME DIPHENYLTRIAZOLES
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Syntheses of 1,3-diphenyl-4H-1,2,4-triazolin-5-thione (1) and 1,5-diphenyl-2H-1,2,4-triazolin-3-thione (2) have been reinvestigated and the structures proposed in the literature corrected. 1H-NMR, 13C-NMR, UV and MS studies of these compounds and their S-
- Somorai, T.,Dvortsak, P.,Lango, J.,Reiter, J.
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- Reactions with N-Acylimino-dithiocarbonic-acid-diesters
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Reactions of N-acylimino-dithiocarbonic-acid-S,S-diesters 1 with nucleophilic compounds present new possibilities to synthesize heterocycles.With amines 1a reacts by mono- and disubstitution, respectively, of methylthio-groups to isothioureas 2 and guanidines 3, with 1,2-binucleophilic arenes to benzoheterocycles 4, with aliphatic diamines to imidazolines 5, pyrimidines 6, diazepines 7 and the hexamethylene-diamine-derivatives 8. 1a reacts also with hydrazines to 1,2,4-triazoles 9 and with hydrazides to the thiosemicarbazones 10 or 1,3,4-oxadiazoles 11.Heterocyclisations of 1 with guanidines, thiourea, salts of thiourea and amidines give the 1,3,5-triazines 12, 14, 15 and 16.N-benzoyl-dithiocarbonic-acid-methylester -amid reacts with CH-acidic compounds to thiazoles 17.The structures of the final products are determined by i.r.-, 1H-n.m.r.-, u.v.- and mass-spectras.
- Augustin, M.,Richter, M.,Salas, S.
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