Simple and efficient catalytic reaction for the selective deuteration of alcohols
A highly efficient system for the catalytic deuteration of α and β CH bonds of primary and secondary alcohols has been developed. The deuterium source is D2O. Together with the low catalyst loadings and the simple experimental setup, the reaction has direct application to the synthesis of bioactive isotopologues and the direct synthesis of fully deuterated substrates, such as ethanol-d6. The current system represents a significant advance in practicality for homogeneous metal catalyzed systems that carry out H/D exchange in organic substrates with water.
Khaskin, Eugene,Milstein, David
p. 448 - 452
(2013/08/25)
METHOD FOR PRODUCING DEUTERATED PERFLUOROALYKYL METHANOL
PROBLEM TO BE SOLVED: To provide a method for safely and efficiently producing a deuterated perfluoroalykyl methanol. SOLUTION: This method for producing the deuterated perfluoroalykyl methanol expressed by general formula (I): RfCD2O-A (Rf is a perfluoroalkyl; and A is D or H) comprises reducing an perfluorcarboxylic acid anhydride expressed by general formula (II): (RfCO)2O by using deuterium in the presence of a transition metal catalyst.
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Page/Page column 7-8
(2008/06/13)
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