- Efficient Synthesis of Acyclic Nucleosides by N-Alkylation of Pyrimidine and Purine-bases Using a New Coupling Agent of Cesium Iodide
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Acyclic nucleosides, ((1,3-bis(benzyloxy)-2-propoxy) methyl)-2-thio-pyrimidine, -uracil, -2-thiouracil, and -2-thioadenine, and (2-acetoxyethoxy methyl)-2-thioadenine, -2-thiopyrimidine, -uracil, and -2-thiouracil have been successfully synthesized in goo
- Kim, Yong Hae,Kim, Joong Young,Lee, Chun Ho
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p. 1045 - 1048
(2007/10/02)
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- Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same
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Novel uracil derivatives of the formula STR1 (wherein R1, R2 R3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.
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- Pyrimidine Acyclic Nucleosides. 1-pyrimidines as Candidate Antivirals
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A number of pyrimidine acyclic nucleosides were synthesized and tested for activity against herpes simplex virus type 1.Synthesis of 1-cytosine (8) and 1-uracil (14) was accomplished in two or three steps
- Kelley, James L.,Kelsey, John E.,Hall, William R.,Krochmal, Mark P.,Schaeffer, Howard J.
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p. 753 - 756
(2007/10/02)
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- ANALOGS OF PYRIMIDINE NUCLEOSIDES. 14. SYNTHESIS AND ANTITUMORIGENIC ACTIVITY OF ALKOXYALKYL DERIVATIVES OF 5-FLUOROURACIL
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A number of alkoxyalkyl derivatives of 5-fluorouracil were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with α-chloro ethers or by the addition of 5-fluorouracil to vinyl ethers.It was established that the synthesized compounds are capable of increasing the lifetimes of mice with L-1210 leukemia and La hemocytoblastosis.The UV and NMR spectra of the synthesized compounds are presented.
- Karpeiskii, M. Ya.,Mikhailov, S. M.,Tsieminya, A. S.,Ziderman, A. A.,Kravchenko, I. M.,et al.
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p. 1176 - 1179
(2007/10/02)
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