77474-49-8 Usage
Chemical composition
A combination of the anti-cancer drug 5-fluorouracil and an acetylated form of ethylene glycol.
Purpose
To enhance the delivery and effectiveness of the anti-cancer drug 5-fluorouracil.
Solubility
Improved solubility in the body due to the acetylated ethylene glycol component.
Stability
Enhanced stability in the body due to the acetylated ethylene glycol component.
Target
Cancer cells, specifically by inhibiting their growth.
Application
Treatment of various types of cancer, including colorectal cancer.
Potential
Represents a potential advancement in the field of cancer treatment and drug delivery.
Mechanism of action
The compound works by targeting and inhibiting the growth of cancer cells, leading to their destruction.
Advantages
Improved solubility, stability, and effectiveness compared to the standalone 5-fluorouracil drug.
Research
Further studies are needed to fully understand the compound's efficacy, safety, and potential side effects in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 77474-49-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,7,4,7 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 77474-49:
(7*7)+(6*7)+(5*4)+(4*7)+(3*4)+(2*4)+(1*9)=168
168 % 10 = 8
So 77474-49-8 is a valid CAS Registry Number.
77474-49-8Relevant articles and documents
Efficient Synthesis of Acyclic Nucleosides by N-Alkylation of Pyrimidine and Purine-bases Using a New Coupling Agent of Cesium Iodide
Kim, Yong Hae,Kim, Joong Young,Lee, Chun Ho
, p. 1045 - 1048 (2007/10/02)
Acyclic nucleosides, ((1,3-bis(benzyloxy)-2-propoxy) methyl)-2-thio-pyrimidine, -uracil, -2-thiouracil, and -2-thioadenine, and (2-acetoxyethoxy methyl)-2-thioadenine, -2-thiopyrimidine, -uracil, and -2-thiouracil have been successfully synthesized in goo
Novel uracil derivatives, process for preparing the same and a pharmaceutical composition containing the same
-
, (2008/06/13)
Novel uracil derivatives of the formula STR1 (wherein R1, R2 R3 and X are defined in the description) and their pharmaceutically acceptable salts, process for preparing the same and pharmaceutical composition containing the same are disclosed. The uracil derivatives have good antitumor activity and, therefore, are useful as antitumor preparation.
Pyrimidine Acyclic Nucleosides. 1-pyrimidines as Candidate Antivirals
Kelley, James L.,Kelsey, John E.,Hall, William R.,Krochmal, Mark P.,Schaeffer, Howard J.
, p. 753 - 756 (2007/10/02)
A number of pyrimidine acyclic nucleosides were synthesized and tested for activity against herpes simplex virus type 1.Synthesis of 1-cytosine (8) and 1-uracil (14) was accomplished in two or three steps
