Preparation of 1-adamantyl ketones: Structure, mechanism of formation and biological activity of potential by-products
Reactions between adamantane-1-carbonyl chloride and several Grignard reagents as well as interactions with solvents have been examined. Some new and unexpected adamantane derivatives were isolated, fully characterized and their biological activity determined. In particular, an unexpected isochromanone 16 was formed in an SEAr process, in which a stable hydrocarbon was the leaving group.
Vicha, Robert,Necas, Marek,Potacek, Milan
p. 709 - 722
(2008/02/01)
A NEW C-PROTECTING GROUP IN PEPTIDE SYNTHESIS. I. PRODUCTION OF 2-(1-ADAMANTYL)-2-PROPANOL ESTERS
During the reaction of benzyloxycarbonylamino acids or halogenoacetic acids with 2-(1-adamantyl)propylene in the presence of sulfuric acid the corresponding esters of 2-(1-adamantyl)-2-propanol are formed.Among the esterification side products the benzyl
Mutulis, F. K.,Polis, Ya. Yu.,Raquel', B. P.,Sekatsis, I. P.,Mishnev, A. F.,Chipens, G. I.