- PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE
-
The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme. (in formula [I] above, the structure represented by formula [II] below: represents any of the structures represented by formula group [III] below: R1, R2, R3, and R4 independently represent a hydrogen atom, a fluorine atom, methyl, or the like, R5 represents any of the structures represented by formula group [IV]:
- -
-
Paragraph 1002
(2020/07/07)
-
- 4H-THIENO[3,2-C]CHROMENE-BASED INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE
-
Compounds that may be used to inhibit Notum Pectinacetylesterase are described, as well as compositions comprising them, and methods of their use to treat diseases and disorders affecting bone.
- -
-
-
- Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: Potent inhibitors of aldosterone synthase
-
Elevated plasma aldosterone levels play a detrimental role in certain forms of congestive heart failure and myocardial fibrosis. We proposed aldosterone synthase (CYP11B2) as a novel target for the treatment of these diseases. In this study, the synthesis
- Ulmschneider, Sarah,Müller-Vieira, Ursula,Mitrenga, Markus,Hartmann, Rolf W.,Oberwinkler-Marchais, Sandrine,Klein, Christian D.,Bureik, Matthias,Bernhardt, Rita,Antes, Iris,Lengauer, Thomas
-
p. 1796 - 1805
(2007/10/03)
-