776328-39-3Relevant articles and documents
PYRIDINE COMPOUND SUBSTITUTED WITH AZOLE
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Paragraph 1002, (2020/07/07)
The present invention provides a compound represented by formula [I] shown below or a pharmaceutically acceptable salt thereof that has an inhibitory effect on 20-HETE producing enzyme. (in formula [I] above, the structure represented by formula [II] below: represents any of the structures represented by formula group [III] below: R1, R2, R3, and R4 independently represent a hydrogen atom, a fluorine atom, methyl, or the like, R5 represents any of the structures represented by formula group [IV]:
Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: Potent inhibitors of aldosterone synthase
Ulmschneider, Sarah,Müller-Vieira, Ursula,Mitrenga, Markus,Hartmann, Rolf W.,Oberwinkler-Marchais, Sandrine,Klein, Christian D.,Bureik, Matthias,Bernhardt, Rita,Antes, Iris,Lengauer, Thomas
, p. 1796 - 1805 (2007/10/03)
Elevated plasma aldosterone levels play a detrimental role in certain forms of congestive heart failure and myocardial fibrosis. We proposed aldosterone synthase (CYP11B2) as a novel target for the treatment of these diseases. In this study, the synthesis