- Phosphorylated arginine analogue, synthesis method and application thereof
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The invention discloses a phosphorylated arginine analogue, a synthesis method and application thereof, and relates to phosphorylated arginine analogues. The phosphorylated arginine analogue is characterized in that a phosphoryl acetamidine structure is adopted as a main body; the phosphorylated arginine analogue can be utilized as hapten for preparing an antibody used for recognizing pArg on protein; the antibody prepared from the phosphorylated arginine analogue has specificity of recognizing pArg, and cross reactivity with other common phosphorylation modification forms in protein is low; besides, a mouse polyclonal antibody prepared from the phosphorylated arginine analogue is mainly of IgG2a type, and can be used for screening monoclonal antibodies; and the phosphorylated arginine analogue can be further utilized as an inhibitor of protein phosphorylated arginine esterase, utilized as a biochemical reagent for studying biological functions of the protein phosphorylated arginine esterase, or a lead compound for medicinal development aimed at the protein phosphorylated arginine esterase.
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Paragraph 0070; 0071; 0072; 0073; 0074; 0075
(2017/05/23)
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- Development of a stable phosphoarginine analog for producing phosphoarginine antibodies
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Protein phosphorylation is one of the most common and extensively studied post-translational modifications (PTMs). Compared to the O-phosphorylation on Ser, Thr and Tyr residues, our understanding of arginine phosphorylation is relatively limited, both in
- Ouyang, Han,Fu, Chuan,Fu, Songsen,Ji, Zhe,Sun, Ying,Deng, Peiran,Zhao, Yufen
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supporting information
p. 1925 - 1929
(2016/02/18)
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- Phosphorus-substituted carbothioamides
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A facile procedure was developed for the synthesis of phosphorus- substituted carbothioamides by the reaction of the corresponding nitriles with O,O-diisopropyl dithiophosphate in the presence of methanol. The structural features and hydrogen bonding in c
- Kozlov,Odinets,Lyssenko,Churusova,Yarovenko,Petrovskii,Mastryukova
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p. 925 - 931
(2007/10/03)
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- Intermediate for (E)-4-[[3-[2-(4-cycloalkyl-2-thiazolyl)ethenyl]phenyl]amino-2,2-alkyldiyl-4-oxobutanoic acids
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The invention relates to a process of making a compound of the formula STR1 wherein R1, R2, R3 and R4 and n are as described herein, and, when R1 is different from R2, and/or when R3 is different from R4, enantiomers, diastereomers and racemates thereof, and salts thereof with pharmaceutically acceptable bases. The method comprises reacting a compound of the formula STR2 wherein R5 and n are as described herein with a compound of the formula STR3 to produce a compound of the formula STR4 wherein n is as described herein, and converting a compound of formula IV to a compound of formula I.
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- A convergent synthesis of Ro24-5913, a novel leukotriene D4 antagonist
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A new and convergent synthesis of the leukotriene D4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial structure optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously.
- Maehr, Hubert,Yang, Roxana
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p. 5445 - 5448
(2007/10/03)
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- Inhibitors of Pyrimidine Biosynthesis. Part 2. The Synthesis of Amidine Phosphonates as Potential Inhibitors of Carbamoyl Phosphate Synthase
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The synthesis of a series of amidine phosphonates (8) and (9) via a thioimidate intermediate is described.
- Wharton, Clifford J.,Wrigglesworth, Roger
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p. 433 - 436
(2007/10/02)
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