- Synthesis and structure-activity relationships of a series of aporphine derivatives with antiarrhythmic activities and acute toxicity
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Some aporphine alkaloids, such as crebanine, were found to present arrhythmic activity and also higher toxicity. A series of derivatives were synthesized by using three kinds of aporphine alkaloids (crebanine, isocorydine, and stephanine) as lead compound
- Wang, Hui,Cheng, Xin,Kong, Shujun,Yang, Zixian,Wang, Hongmei,Huang, Qiuyan,Li, Jingyu,Chen, Cheng,Ma, Yunshu
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- Total synthesis of sinomendine and its analogs
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Sinomendine (1), a good receptor antagonist of angiotensin II and rare oxoaporphine alkaloid isolated from traditional Chinese drug Sinomenium acutum (Thunb.) Rehd. et Wils, was synthesized from a bromobenzylidenetetrahydroisoquinolineenamide precursor (6). Photocyclization of this enamide led to a protected aporphine (7), which could be converted into oxoaporphine (9) and (±)-sinomendine (1) by Fremy's salt oxidation followed an available Grignard reaction.
- Zhou, De-Min,Yue, Bao-Zhen,Cui, Ji-Qiao,Cai, Meng-Shen,Zhang, Li-He
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p. 439 - 450
(2007/10/03)
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- THE ALKALOIDS OF STEPHANIA SASAKII: STRUCTURE OF FIVE NEW ALKALOIDS
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Five new alkaloids, dehydrocrebanine, 4,5-dioxodehydrocrebanine, stesakine, dehydrostesakine, bisaknidinine and four known alkaloids, lirodenine, lanuginosine, 1-tetrahydropalmatine, d-isocorydine with a few alkaloids of unknown structure were newly isolated from Stephania sasakii.The structures of the new alkaloids were determined from spectral data and chemical evidence. - Key Word Index : Stephania sasakii; Menispermaceae; dehydrocrebanine; 4,5-dioxodehydrocrebanine; bisaknadinine; stesakine; dehydrostesakine.
- Kunitomo, Jun-Ichi,Murakami, Yoshiko,Oshikata, Megumi,Shingu, Tetsuro,Akasu, Michinori,at al.
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p. 2735 - 2740
(2007/10/02)
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