- Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes
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A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.
- Liao, Jianning,Dong, Jipan,Xu, Jiaqing,Wang, Wei,Wu, Yongjun,Hou, Yuxia,Guo, Hongchao
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supporting information
p. 2090 - 2099
(2021/02/05)
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- Tandem grinding reactions involving aldol condensation and Michael addition in sequence for synthesis of 3,4,5-trisubstituted isoxazoles
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A one-pot, base-catalyzed, tandem grinding process involving carrying out aldol condensation and Michael addition in sequence to produce 3,4,5-trisubstituted isoxazoles from 3,5-dimethyl-4-nitroisoxazole, aromatic aldehydes and activated methylene compoun
- Hu, Xiao-Mu,Dong, Hai,Li, Yue-Dan,Huang, Ping,Tian, Zhuang,Wang, Ping-An
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p. 27883 - 27887
(2019/09/30)
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- An efficient solvent-free synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using solid nano-titania
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Abstract: An efficient and solvent-free procedure for the synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using nano-titania as solid support and recyclable catalyst is presented. This method provides clean, simple, solvent-free and useful alternative to
- Dwivedi, Kartikey Dhar,Marri, Sameer Reddy,Nandigama, Satish Kumar,Chowhan, Raju L
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- One-pot synthesis of functionalized isoxazole-thiolane hybrids via Knoevenagel condensation and domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions
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One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactio
- Nagaraju, Sakkani,Satyanarayana, Neeli,Paplal, Banoth,Vasu, Anuji K.,Kanvah, Sriram,Sridhar, Balasubramanian,Sripadi, Prabhakar,Kashinath, Dhurke
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p. 94474 - 94478
(2015/11/17)
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- Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam
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Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).
- Zhang, Jinlong,Liu, Xihong,Ma, Xiaojuan,Wang, Rui
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p. 9329 - 9331
(2013/10/01)
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- Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles
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We have investigated the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles. This study revealed that the title compounds were optimal Michael acceptors toward thiols. A procedure was also established to prepare isoxazole-containing sul
- Bruschi, Simone,Moccia, Maria,Adamo, Mauro F.A.
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experimental part
p. 3602 - 3604
(2011/07/31)
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- Multicomponent synthesis of spiroisoxazolines
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A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.
- Adamo, Mauro F. A.,Donati, Donato,Duffy, Eleanor F.,Sarti-Fantoni, Piero
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p. 8395 - 8399
(2007/10/03)
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- Michael additions on isoxazole derivatives under solvent-free conditions
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Knoevenagel condensation of 3,5-dimethyl-4-nitro-isoxazole 1 with aromatic aldehydes in solid state in the presence of piperidine gives 3-methyl-4-nitro-5-styryl-isoxazoles 2 in excellent yields within few minutes. Michael addition of active methylene com
- Rajanarendar,Ramesh,Karunakar
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p. 1994 - 1996
(2007/10/03)
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