78080-53-2

Basic information

• Product Name: Isoxazole, 3-methyl-4-nitro-5-[2-(4-nitrophenyl)ethenyl]-
• CAS NO: 78080-53-2
• Molecular Formula: C12H9N3O5
• Molecular Weight: 275.221
• Mol File: 78080-53-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Isoxazole, 3-methyl-4-nitro-5-[2-(4-nitrophenyl)ethenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Isoxazole, 3-methyl-4-nitro-5-[2-(4-nitrophenyl)ethenyl]-(78080-53-2)
• EPA Substance Registry System: Isoxazole, 3-methyl-4-nitro-5-[2-(4-nitrophenyl)ethenyl]-(78080-53-2)

Safety Data

• Hazardous Substances Data: 78080-53-2(Hazardous Substances Data)

Upstream product

• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 123-54-6 acetylacetone 
• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 1314231-04-3 5-(2-benzylsulfanyl-2-(4-nitrophenyl)ethyl)-3-methyl-4-nitroisoxazole 
• 1316316-22-9 C₂₉H₂₇N₅O₉ 
• 1229422-29-0 2-(3-methyl-4-nitroisoxazol-5-yl)-1-(4-nitrophenyl)ethanesulfonic acid 
• 1021951-88-1 (1S,2R)-1-(3-methyl-4-nitro-isoxazol-5-yl)-2-(4-nitro-phenyl)-ethane-1,2-diol 
• 81282-90-8 3-[2-(3-methyl-4-nitroisoxazol-5-yl)-1-(4-nitrophenyl)ethyl]pentane-2,4-dione 

Relevant articles and documents

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

An efficient solvent-free synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using solid nano-titania

Abstract: An efficient and solvent-free procedure for the synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using nano-titania as solid support and recyclable catalyst is presented. This method provides clean, simple, solvent-free and useful alternative to

Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).