- A-[(E)-2-(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPTHALENYL)-1-PROPENYL]BENZOIC ACID ANALOGS AND METHOD OF MANUFACTURE AND AND USE THEREOF
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Analogs of 4-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-napthalenyl)-1 - propenyl]benzoic acid and methods of manufacture and use thereof, such as for use in cancer prevention and treatment.
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Page/Page column 11
(2008/06/13)
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- SELECTIVE REACTIONS OF α-ARYL WITTIG REAGENTS WITH THE FORMYL MOIETY OF 4-FORMYLBENZOYL CHLORIDE
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The benzylic Wittig reagents 2a, 2b and 2e react with 4-formylbenzoyl chloride 1 to give 40-60percent yields of products 3 derived from selective attack at the formyl group of 1; The same selectivity is not found for the non-stabilized ylids 2c and 2d or
- Waetjen, Frank,Dahl, Otto,Buchardt, Ole
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p. 4741 - 4744
(2007/10/02)
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- Arotinoids, a new class of highly active retinoids
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The synthesis and biological activity of new aromatic retinoids are reported. The most active ones belong to a chemical class of compounds, which we have termed 'arotinoids'. For the compound p-[(E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-propenyl)]-benzoic acid ethyl ester, a therapeutic potency in the antipapilloma test was found which exceeds that of retinoic acid by a factor of 8000, while the concurrently observed toxic hypervitaminosis A effects are only increased by a factor of 800. The structural relationship of the arotinoids with retinoic acid is demonstrated; the arotinoids contain the retinoic acid carbon skeleton in a fixed cisoid geometric conformation.
- Loeliger,Bollag,Mayer
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