- PROCESS FOR THE PREPARATION OF 2,2-DIFLUOROETHYLAMINE
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A process for the preparation of 2,2-difluoroethylamine, comprising the reaction of 2,2-difluoro-1-chloroethane with an imide of the formula (II) in the presence of an acid scavenger, to give a compound of the formula (III) in which, in the compounds of the formulae (II) and (III), R1 and R2 are, each independently of one another, hydrogen or C1-C6-alkyl or R1 and R2 form, together with the carbon atoms to which they are bonded, a six-membered aromatic ring which is optionally substituted; and the cleavage of 2,2-difluoroethylamine by reaction of the compound of the formula (III) with acid, base or hydrazine.
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Page/Page column 6
(2012/07/31)
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- PROCESS FOR PREPARING 2,2-DIFLUOROETHYLAMINE AND SALTS THEREOF PROCEEDING FROM DIFLUOROACETONITRILE
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The present invention relates to a process for preparing 2,2-difluoroethylamine of the formula (I) and salts thereof, for example sulphates, hydrochlorides or acetates, which proceeds from difluoroacetonitrile.
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Page/Page column 3
(2011/07/29)
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- Process for Preparing 2,2-difluoroethylamine by Hydrogenating 1,1-difluoro-2-nitroethane
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Process for preparing 2,2-difluoroethylamine, characterized in that 1,1-difluoro-2-nitroethane is subjected to a catalytic hydrogenation.
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Page/Page column 3
(2011/04/24)
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- N-(Fluoroethyl)(imidazolylphenyl)formamidines. The issue of the active species of mifentidine
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Three N-fluoroethyl-substituted (imidazolylphenyl)formamidine derivatives, namely, 2-fluoroethyl (3b), 2,2-difluoroethyl (3c), and 2,2,2-trifluoroethyl (3d), were prepared to test the effect of fluorine substitution on basicity and, then on H2-
- Donetti,Cereda,Ezhaya,Micheletti
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p. 957 - 961
(2007/10/02)
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