- Nitrogen-containing ring derivative inhibitor as well as preparation method and application thereof
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The invention relates to a nitrogen-containing ring derivative inhibitor as well as a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound, and uses of the compound as a P2X3 inhibitor in treatment of P2X3 receptor dysfunction diseases, especially in treatment of neurogenic diseases.
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Paragraph 0759-0761; 0766-0769
(2021/05/12)
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- 5- OR 7-AZAINDAZOLES AS BETA-LACTAMASE INHIBITORS
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The present invention relates to β-lactamase inhibitors having the following general formula (I): wherein R1-R4 and X1-X2 are defined in the specification, pharmaceutical composition thereof, and use thereof for the treatment of a bacterial infection, alone or in combination with β-lactam antibiotics and/or other antibiotics and/or other β-lactamase inhibitors.
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Page/Page column 41; 43; 44
(2020/09/19)
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- NOVEL PYRAZOLO-PYRROLO-PYRIMIDINE-DIONE DERIVATIVES AS P2X3 INHIBITORS
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The present invention covers substituted Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.
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Page/Page column 103
(2019/05/15)
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- AURORA KINASE INHIBITORS
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Disclosed herein inter alia are compositions and methods useful in the treatment of cancer and for modulating the activity of Aurora A kinase and/or a Myc family protein.
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- Synthesis and Hypocholesterolemic Activity of 6,7-Dihydro-4H-pyrazolopyrrolopyrimidine-5,8-diones, Novel Inhibitors of AcylCoA:Cholesterol O-Acyltransferase
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A novel series of 6,7-dihydro-4H-pyrazolopyrrolopyrimidine-5,8-dione inhibitors of the enzyme acylCoA:cholesterol O-acyltransferase is described.A number of these derivatives were found to be potent modulators of serum lipoprotein levels in
- Larsen, Scott D.,Spilman, Charles H.,Bell, Frank P.,Dinh, Dac M.,Martinborough, Esther,Wilson, Gracella J.
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p. 1721 - 1727
(2007/10/02)
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