- Synthesis and calcium channel antagonist activity of 1,4-dihydropyridine derivatives containing 4-nitroimidazolyl substituents
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Alkyl, cycloalkyl and arylalkyl ester analogues of nifedipine (CAS 21829-25-4), in which the ortho-nitro phenyl group at position 4 is replaced by 1-methyl-4-nitro-5-imidazolyl substituent, were synthesized and evaluated as calcium channel antagonists usi
- Shafiee, Abbas,Rastkary, Noushin,Jorjani, Masoumeh
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p. 537 - 542
(2007/10/03)
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- Synthesis and Antihypertensive Activities of New 1,4-Dihydropyridine Containing Nitroimidazolyl Substituent with a Nitrooxy Group at the 3-Ester Position
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New analogues of nifedipine, in which the ortho nitrophenyl group of position 4 is replaced by 1-methyl-4-nitro-5-imidazolyl or 1-methyl-5-imidazolyl with a nitrooxy group at the 3-ester position were synthesized, and the antihypertensive activity of the compounds was examined by the tail-cuff method and compared with TNG and nifedipine. Compounds 11g, 11i-m, 11o, 11r, and 11v showed activity similar to nifedipine and TNG.
- Shafiee, Abbas,Rastkary, Noushin,Jorjani, Masoumeh,Shafaghi, Bijan
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- Synthesis of Some New Imidazole Derivatives
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N-Protected (CH2Ph, CH3) 4-nitroimidazoles (1) react with carbanions of tert-butyl chloroacetate, chloroacetonitrile and chloroform, affording Vicarious Nucleophilic Substitution of Hydrogen (VNS) products 2, 3, and 7, respectively.These compounds, after
- Ostrowski, S.
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p. 2237 - 2248
(2007/10/02)
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- 4,5-DISUBSTITUTED IMIDAZOLES. PART I. 4-HYDROXYMETHYL-5-NITROIMIDAZOLE, 4-FORMYL-5-NITROIMIDAZOLE AND THEIR N-SUBSTITUTED DERIVATIVES
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A synthesis of 4-hydroxymethyl-5-nitroimidazole, 4-formyl-5-nitroimidazole, their N-methyl and N-trityl derivatives were developed starting from easily accessible 4-hydroxymethylimidazole.The structures of N-substituted derivatives have been assumed on the basis of analyzing the 1H NMR data.
- Bochwic, Boleslaw,Frankowski, Andrzej,Kuswik, Gabriela,Seliga, Czeslawa
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p. 1055 - 1061
(2007/10/02)
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