Asymmetric SN 1 α-Alkylation of cyclic ketones catalyzed by functionalized chiral ionic liquid (FCIL) organocatalysts
Ionic liquid works better: The first intermolecular asymmetric α-alkylation of cyclic ketones was realized by using functionalized chiral ionic liquids as catalysts. The reaction proceeded with good to excellent yields and high ee. Highly stereoselective desymmetrization of 4-substituted cyclohexanones with >99:1 d.r. and up to 87 % ee were achieved by using this protocol. (Chemical Equation Representation).
Functionalized chiral ionic liquid catalyzed asymmetric SN1 α-alkylation of ketones and aldehydes
Pyrrolidine-derived functionalized chiral ionic liquids (FCILs) have been found to catalyze asymmetric SN1 α-alkyl-ations of ketones and aldehydes with up to 99% yield, >99:1 dr and 87% ee. The FCIL catalysts enable SN1 α-alkylations