cas 86129-63-7, ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE | Articles data ｜lookchem

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86129-63-7

Articles about 86129-63-7Total 4 be found

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SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH
The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
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Page/Page column 44

(2009/04/24)

Thermal Cyclization of 3-Acyl-4-azidopyridines to Isoxazolo[4,3-c]pyridines
4-Azidopyridines such as 3-acetyl-4-azido-2-pyridones 3 or 4-azido-3-ethoxycarbonylpyridine 7 with reactive ortho-acyl substituents were obtained from the 4-hydroxy-2-pyridones 1, resp. 5 via 4-tosyloxy-2-pyridones 2 or the 2,4-dichloropyridine 6. DSC-ass
Stadlbauer, Wolfgang,Fiala, Werner,Fischer, Michaela,Hojas, Gerhard
p. 33 - 39
(2007/10/03)

An Easy and Convenient Synthesis of 6-Methyl-4(1H)-pyridone-3-carboxylic Acid
A new and easy synthesis of 6-methyl-4(1H)-pyridone-3-carboxylic acid (5), an important component of broad spectrum cephalosporins, is described.It starts from the readily available ethyl 4-hydroxy-6-methyl-2(1H)-pyridone-3-carboxylate (1), which is treated with phosphoryl chloride to give ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (2).Selective substitution of the chlorine in 4-position with alkoxide ion leads to the 4-alkoxypyridine derivatives 3.Hydrogenolysis of 3 affords ethyl 4-alkoxy-6-methyl-pyridine-3-carboxylates 4; which are hydrolysed to 5 in one step.
Mittelbach, Martin
p. 479 - 480
(2007/10/02)

Aza Analogues of Lucanthone: Synthesis and Antitumor and Bactericidal Properties
Three types of aza analogues of lucanthone were synthesized for evaluation as antitumor drugs.None of the compounds was found to have significant cytotoxic effects either on Friend tumor cells or on L1210 leukemia cells.However, one of the target compound
Croisy-Delcey, Martine,Bisagni, Emile
p. 1329 - 1333
(2007/10/02)

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Chemical Properties

Appearance/Colour :Solid
Melting Point: 53 °C
Boiling Point: 298.2 °C at 760 mmHg
Flash Point:134.1 °C
Density: 1.32 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 0.00129mmHg at 25°C
Refractive Index: 1.537
PKA: -0.22±0.10(Predicted)
PSA: 39.19000
LogP: 2.87350

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