86129-63-7

Basic information

• Product Name: ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE
• Synonyms: BUTTPARK 43\57-69;AURORA KA-4546;ETHYL 2,4-DICHLORO-6-METHYLNICOTINATE;ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE;ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE 95+%;EthylEster,2,4-Dichloro-6-Methyl-3-PyridinecarboxylicAcid;2,4-Dichloro-6-methyl-nicotinic acid ethyl ester;Ethyl 2,4-dichloro-6-methyl-3-pyridinecarboxylate
• CAS NO: 86129-63-7
• Molecular Formula: C₉H₉Cl₂NO₂
• Molecular Weight: 234.08
• Product Categories: pharmacetical
• Mol File: 86129-63-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 53 °C
• Boiling Point: 298.2 °C at 760 mmHg
• Flash Point: 134.1 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 0.00129mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.22±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE(86129-63-7)
• EPA Substance Registry System: ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE(86129-63-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 86129-63-7(Hazardous Substances Data)

Usage

General Description

ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE is a chemical compound with the molecular formula C9H8Cl2NO2. It is a pyridine derivative and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE is known for its insecticidal and pesticidal properties and is used in the formulation of various insecticides and herbicides. Additionally, it is also used as a building block in the production of fine chemicals and pharmaceuticals.ETHYL 2,4-DICHLORO-6-METHYLPYRIDINE-3-CARBOXYLATE is a colorless to light yellow liquid with a characteristic odor, and it is essential to handle with care due to its toxic and potentially hazardous nature.

InChI:InChI=1/C9H9Cl2NO2/c1-3-14-9(13)7-6(10)4-5(2)12-8(7)11/h4H,3H2,1-2H3

Upstream product

• 10350-10-4 ethyl 2,4-dihydroxy-6-methylnicotinate 
• 105-53-3 diethyl malonate 
• 10350-10-4 ethyl 1,2-dihydro-2-oxo-4-hydroxy-6-methylpyridine-3-carboxylate 

Downstream Products

• 33821-58-8 6-methyl-4-oxo-1,4-dihydropyridine-3-carboxylic acid 
• 111974-39-1 Ethyl 4-ethoxy-6-methylpyridine-3-carboxylate 
• 38367-36-1 2,4-dichloro-6-methyl-3-pyridinecarbonitrile 
• 1347759-32-3 C₂₄H₂₅ClN₆O₂ 
• 1347759-31-2 2-(1-(4-methoxybenzyl)-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl)-N,N-dimethylisonicotinamide 
• 1347759-30-1 2-(1-(4-methoxybenzyl)-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridine-3-yl)isonicotinic acid 
• 1347759-29-8 methyl 2-(1-(4-methoxybenzyl)-6-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl)isonicotinate 
• 1347759-28-7 1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-3-(trimethylstannyl)-1H-pyrazolo[4,3-c]pyridin-4-amine 
• 1347759-27-6 3-iodo-1-(4-methoxybenzyl)-6-methyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]pyridin-4-amine 
• 1347759-26-5 4-chloro-3-iodo-1-(4-methoxybenzyl)-6-methyl-1H-pyrazolo[4,3-c]pyridine 
• 1159828-70-2 4-chloro-6-methyl-1H-pyrazolo[4,3-c]pyridine 
• 1347759-24-3 3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbonitrile 
• 1347759-23-2 3-iodo-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine-6-carbaldehyde 
• 1347758-92-2 C₁₄H₁₉N₃O 

Relevant articles and documents

SULFONYL AMIDE DERIVATIVES FOR THE TREATMENT OF ABNORMAL CELL GROWTH

The present invention relates to a compound of the formula I wherein R1 to R6, A, B, n and m are as defined herein. Such novel sulfonyl amide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

An Easy and Convenient Synthesis of 6-Methyl-4(1H)-pyridone-3-carboxylic Acid

A new and easy synthesis of 6-methyl-4(1H)-pyridone-3-carboxylic acid (5), an important component of broad spectrum cephalosporins, is described.It starts from the readily available ethyl 4-hydroxy-6-methyl-2(1H)-pyridone-3-carboxylate (1), which is treated with phosphoryl chloride to give ethyl 2,4-dichloro-6-methylpyridine-3-carboxylate (2).Selective substitution of the chlorine in 4-position with alkoxide ion leads to the 4-alkoxypyridine derivatives 3.Hydrogenolysis of 3 affords ethyl 4-alkoxy-6-methyl-pyridine-3-carboxylates 4; which are hydrolysed to 5 in one step.