E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: Probing the requirements for Alzheimer's amyloidogenesis
Herein, we report a stereospecific E-olefin dipeptide isostere synthesis that can be used to make gram quantities of the Phe-Phe isostere desired for eliminating a specific backbone H-bond donor and acceptor in the Alzheimer's disease related Aβ peptide.
Fu, Yanwen,Bieschke, Jan,Kelly, Jeffery W.
p. 15366 - 15367
(2007/10/03)
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