870301-33-0

Basic information

• Product Name: [3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone
• Synonyms: [3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone
• CAS NO: 870301-33-0
• Molecular Weight: 464.561
• Mol File: 870301-33-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: [3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone(870301-33-0)
• EPA Substance Registry System: [3(5S),4R,5S]-3-[5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone(870301-33-0)

Safety Data

• Hazardous Substances Data: 870301-33-0(Hazardous Substances Data)

Upstream product

• 82042-48-6 (S)-5-<(tert-Butoxycarbonyl)amino>-6-phenyl-(E)-3-hexenoic acid 
• 77943-39-6 4-methyl-5-phenyloxazolidin-2-one 

Downstream Products

• 137278-30-9 methyl (2R,5S)-2-benzyl-5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoate 
• 108385-61-1 5(S)--6-phenyl-2(R)-(phenylmethyl)-3-trans-hexenoic acid 
• 870301-34-1 [3(2R,5S),4R,5S]-3-[2-benzyl-5-t-butoxycarbonylamino-6-phenyl-E-3-hexenoyl]-4-methyl-5-phenyl-2-oxazolidinone 

Relevant articles and documents

E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: Probing the requirements for Alzheimer's amyloidogenesis

Herein, we report a stereospecific E-olefin dipeptide isostere synthesis that can be used to make gram quantities of the Phe-Phe isostere desired for eliminating a specific backbone H-bond donor and acceptor in the Alzheimer's disease related Aβ peptide.