- Two new abietane diterpenoids from Salvia yunnanensis
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Two new abietane diterpenoids, yunnannin A (1) and danshenol C (2), were isolated from Salvia yunnanensis together with ten known diterpenoids, danshenol A (3), przewalskin (4), tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8, 11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds 1-3 were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound 3 showed inhibited growth of K562 (IC 50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines while compound 2 was inactive. Compound 1 showed moderate inhibitory activity on QGY (IC50 = 16.75 μg/mL) and Me180 (IC50 = 5.84 μg/mL) cells. Georg Thieme Verlag KG Stuttgart.
- Xu, Gang,Peng, Li-Yan,Lu, Lei,Weng, Zi-Ying,Zhao, Yu,Li, Xiao-Li,Zhao, Qin-Shi,Sun, Han-Dong
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- TOTAL SYNTHESIS OF DAN SHEN DITERPENOID QUINONES
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A photochemical aromatic annulation strategy provides efficient synthetic routes to the diterpenoid quinones (+)-danshexinkun A, danshexinkun B, danshexinkun C, (-)-dihydrotanshinone I, and tanshinone I.
- Danheiser, Rick L.,Casebier, David S.,Loebach, Jennifer L.
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p. 1149 - 1152
(2007/10/02)
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