87205-99-0

Basic information

• Product Name: Dihydrotanshinone I
• Synonyms: (-)-1,2-Dihydro-1,6-dimethylphenanthro[1,2-b]furan-10,11-dione;1,6-Dimethyl-1,2,10,11-tetrahydrophenanthro[1,2-b]furan-10,11-dione;4,17-Dimethyl-15-oxagona-1,3,5(10),6,8,13-hexene-11,12-dione;Dihydrotanshinone I;15,16-Dihydrotanshine I;1,6-DiMethyl-1,2-dihydrophenanthro[1,2-b]furan-10,11-dione;Dihydrotanshinone I, 15,16-Dihydrotanshinone I;(1R)-1,6-diMethyl-1,2-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione
• CAS NO: 87205-99-0
• Molecular Formula: C₁₈H₁₄O₃
• Molecular Weight: 278.3
• Product Categories: chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 87205-99-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 214.0 to 218.0 °C
• Boiling Point: 479.2 °C at 760 mmHg
• Flash Point: 215 °C
• Appearance: red/
• Density: 1.32 g/cm³
• Vapor Pressure: 2.41E-09mmHg at 25°C
• Refractive Index: 1.67
• Storage Temp.: 2-8°C
• Solubility: ethanol: soluble1mg/mL, clear, orange to red
• CAS DataBase Reference: Dihydrotanshinone I(CAS DataBase Reference)
• NIST Chemistry Reference: Dihydrotanshinone I(87205-99-0)
• EPA Substance Registry System: Dihydrotanshinone I(87205-99-0)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-50
• Safety Statements: 61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: SF8282630
• Hazardous Substances Data: 87205-99-0(Hazardous Substances Data)

Usage

Chemical Properties

Red powder

Uses

Dihydrotanshinone I, an extract from Salvia miltiorrhiza Bunge, is an anti-cancer agent which has been shown to induce apoptosis in human colorectal cancer cells.

InChI:InChI=1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1

Upstream product

• 141040-33-7 (+)-danshexinkun A 
• 140886-42-6 2-[(R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-8-methyl-3-triisopropylsilanyloxy-phenanthren-1-ol 
• 189308-08-5 (1R,10S)-1,10-dihydro-10-hydroxy-1,6-dimethyl-10-(2-oxopropyl)phenanthro[1,2-b]furan-11(2H)-one 
• 189308-08-5 danshenol C 
• 140886-40-4 2-Diazo-1-(5-methyl-naphthalen-1-yl)-ethanone 
• 67757-61-3 1-(5-methyl-[1]naphthyl)-ethanone 

Downstream Products

• 568-73-0 Tanshinone I 
• 126979-79-1 1,2-dihydro-1,6-dimethylfuro<3,2-c>naphth<2,1-e>oxepine-10-12-dione 

Relevant articles and documents

Two new abietane diterpenoids from Salvia yunnanensis

Two new abietane diterpenoids, yunnannin A (1) and danshenol C (2), were isolated from Salvia yunnanensis together with ten known diterpenoids, danshenol A (3), przewalskin (4), tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8, 11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds 1-3 were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound 3 showed inhibited growth of K562 (IC 50 = 0.53 μg/mL), T-24 (IC50 = 7.94 μg/mL), QGY (IC50 = 4.65 μg/mL) and Me180 (IC50 = 6.89 μg/mL) cell lines while compound 2 was inactive. Compound 1 showed moderate inhibitory activity on QGY (IC50 = 16.75 μg/mL) and Me180 (IC50 = 5.84 μg/mL) cells. Georg Thieme Verlag KG Stuttgart.