- Modular Synthesis of Polysubstituted Quinolin-3-amines by Oxidative Cyclization of 2-(2-Isocyanophenyl)acetonitriles with Organoboron Reagents
-
Polysubstituted quinolin-3-amines are vital structural motifs because of their broad biological activities as well as versatile transformational abilities. However, they are not easily accessible. We disclose a protocol with Mn(III) acetate as a mild one-
- Wang, Shihui,Xu, Jian,Song, Qiuling
-
p. 6789 - 6794
(2021/09/02)
-
- Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co-Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions
-
A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity.
- Choi, Isaac,Chung, Hyunho,Park, Jang Won,Chung, Young Keun
-
p. 5508 - 5511
(2016/11/17)
-
- Method for synthesizing indole derivative
-
The invention relates to a method for synthesizing an indole derivative shown in the formula (III) (please see the specification). The method includes the steps that in a solvent and inertia gas atmosphere, when a catalyst, a nitrogen-containing ligand, an acid accelerator and KF exist, a compound in the formula (I) (please see the specification) and a compound in the formula (II) (please see the specification) are reacted, aftertreatment is carried out after the reaction is completed, and therefore the compound in the formula (III) is obtained, wherein R1 is selected from H or halogen, and R2 is selected from H, C1-C6 alkyl, C1-C6 alkoxy or halogen. According to the method, as a proper substrate, the proper catalyst, the proper nitrogen-containing ligand, the proper acid accelerator, the proper KF, the proper solvent and the like are comprehensively selected and cooperated, the range of the substrate is expanded accordingly, the indole derivative can be obtained with the good yield, the method has good application prospects and research value in the field of organic chemistry synthesis, and a brand new method is provided for synthesis of the compound.
- -
-
Paragraph 0068; 0069; 0070; 0071
(2016/10/10)
-
- N1-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS
-
The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of the compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions there-of; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal
- -
-
-
- N2-PYRAZOLOSPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS
-
The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, R3 and R4 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of an acetyl- CoA carboxylase enzyme(s) in an animal.
- -
-
-