- Pharmaceutical preparation for improving the bioavailability of drugs which are difficult to absorb and a procedure for obtaining it
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The preparation consists of millispheres, microspheres, nanospheres or array-type particles consisting of a nucleus of a gellable hydrocolloid onto which has been deposited a film of a cationic polysaccharide, and incorporating inside a pharmacologically useful drug. The procedure consists of dissolving, suspending or emulsifying the drug in a solution of the gellable hydrocolloid; adding the resulting mixture to a gelling solution; and suspending the resulting millispheres, microspheres, nanospheres or array-type particles in a solution of the cationic polysaccharide.
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- Method for immobilizing enzymes and microbial cells
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A method for immobilizing enzymes or microbial cells which comprises the steps of uniformly mixing an aqueous dispersion of enzymes or microbial cells with a photo-curable resin having a number average molecular weight of 800 to 100,000, two or more photopolymerizable ethylenically unsaturated groups per molecule and hydrophilic groups, and irradiating actinic rays to the above mixture of photo-curable resin and enzymes or microbial cells. The immobilized product is advantageously used in various enzymatic reactions with stable enzyme activity.
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- Immobilization of proteins with polyurethane polymers
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A protein which can be an enzyme is immobilized by: (a) admixing the protein and an isocyanate-capped liquid polyurethane prepolymer in the absence of water to form a resulting mixture (an intermediate product); and (b) forming the intermediate product by reacting it with water to form a polyurethane foam comprising the immobilized enzyme. When certain proteins in sufficient amount are mixed with the prepolymer in the absence of water the resultant protein prepolymer mixture will solidify to produce a solid non-foamed product containing a protein immobilized therein. Initially mixing the protein and prepolymer in the absence of water results in immobilization of a substantially greater amount of protein than when water is present.
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