A formal, stereocontrolled synthesis of lactacystin has been completed from t-Bu-O-l-serine, providing the key intermediate 13, also useful for the generation of a range of C-9 analogues.
Bulman Page, Philip C.,Goodyear, Ross L.,Chan, Yohan,Slawin, Alexandra M. Z.,Allin, Steven M.
p. 30019 - 30032
(2019/10/01)
Development of a Method for the N-Arylation of Amino Acid Esters with Aryl Triflates
A general method for the N-arylation of amino acid esters with aryl triflates is described. Both α- and β-amino acid esters, including methyl, tert-butyl, and benzyl esters, are viable substrates. Reaction optimization was carried out by design of experim
King, Sandra M.,Buchwald, Stephen L.
supporting information
p. 4128 - 4131
(2016/08/30)
NOVEL COMPOUNDS
This invention relates to novel amide derivatives and salts thereof. More particularly, it relates to novel amide derivatives and salts thereof which act as a ROCK inhibitor, to a pharmaceutical composition comprising the same and to a method of using the same therapeutically in the treatment and/or prevention of ROCK-related disease.
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Page/Page column 24-25
(2008/06/13)
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