- Decarboxylative formation of N-alkyl pyrroles from 4-hydroxyproline
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N-Alkyl pyrroles are obtained in a single step from 4-hydroxyproline and aldehydes in just 15 min under microwave irradiation.
- Deb, Indubhusan,Coiro, Daniel J.,Seidel, Daniel
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scheme or table
p. 6473 - 6475
(2011/06/28)
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- Synthesis and nuclear magnetic resonance spectroscopic studies of 1- arylpyrroles
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A series of m- and p-substituted 1-phenyl, 1-benzyl, 1-benzoyl, and 1- (2-phenylethyl)pyrroles was prepared and their 1H and 13C nmr spectroscopic characteristics were examined. In general, good correlations were observed between the chemical shift values of the β-H and the β-C of pyrroles [except 1-(2-phenylethyl)pyrroles] and the Hammettt σ. The observation may be explained in terms of the electronic effects of the substituents which are transmitted through bonds and through space by interaction of the p orbitals between β-Cs of the pyrrole ring and m- and p- Cs of the phenyl ring. Substituent constants of 1-pyrrolyl, 1-pyrrolylmethyl, and 1-pyrroloyl groups for the 1H and 13C chemical shifts of phenyl ring are also presented.
- Lee, Chang Kiu,Jun, Jung Ho,Yu, Ji Sook
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