Metabolism of bromocarbamides. I. In vitro degradation of carbromal and acetylcarbromal in rabbit liver
10,000 g supernatant of rabbit liver homogenate catalyzes the deacetylation of acetylcarbromal to carbromal. Cis 2 ethyl crotonylurea was proved to be the in vitro debromination product. Trans 2 ethyl crotonylurea and 2 ethyl butyrylurea could be excluded to be primary metabolites of carbromal in this enzyme preparation by comparison of melting points and spectroscopic properties. N Acetyl 2 ethyl crotonylurea, a primary debromation product of acetylcarbromal, could not be detected.
Sticht,Kaferstein
p. 1021 - 1023
(2007/10/12)
Separation of ethylenic cis and transisomers by paper chromatography. Application to the isomers of 2-ethylcrotonylurea.