95-04-5 Usage
Originator
Nostyn,Ames,US,1956
Manufacturing Process
54 g of carbromal (2-bromo-2-ethylbutyryl-urea) in 600 cc of isopropanol was
stirred and refluxed for 3 hours with 27.8 g of anhydrous silver oxide. The
reaction mixture was filtered and the silver residue was extracted with 100 cc
of boiling isopropanol. The filtered and dried solids which separated weighed
22.5 g and melted at 189°C to 190.5°C. Concentration of the filtrate yielded
an additional 3.3 g of product which melted at 160°C to 170°C. These two
crops were separately obtained as white needles by crystallization from
alcohol and exhibited slight solubility in water. The first crop gave 21.7 g of 2-
ethyl-cis-crotonyl urea with a melting point of 191°C to 193°C, and the
second crop gave 0.9 g with a melting point of 191°C to 193°C for a total
yield of 42.4 g or 63% of the theoretical.
Check Digit Verification of cas no
The CAS Registry Mumber 95-04-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 95-04:
(4*9)+(3*5)+(2*0)+(1*4)=55
55 % 10 = 5
So 95-04-5 is a valid CAS Registry Number.
95-04-5Relevant articles and documents
Metabolism of bromocarbamides. I. In vitro degradation of carbromal and acetylcarbromal in rabbit liver
Sticht,Kaferstein
, p. 1021 - 1023 (2007/10/12)
10,000 g supernatant of rabbit liver homogenate catalyzes the deacetylation of acetylcarbromal to carbromal. Cis 2 ethyl crotonylurea was proved to be the in vitro debromination product. Trans 2 ethyl crotonylurea and 2 ethyl butyrylurea could be excluded to be primary metabolites of carbromal in this enzyme preparation by comparison of melting points and spectroscopic properties. N Acetyl 2 ethyl crotonylurea, a primary debromation product of acetylcarbromal, could not be detected.
