A NEW METHOD FOR NUCLEOPHILIC OXYMETHYLATION USING α-ALKOXYSILANES. SYNTHESIS OF UNSYMMETRICAL 1,2-DIOLS
Desilylation of α-alkoxysilanes offers the convenient generation of carbinyl carbanions which react with a variety of carbonyl compounds giving mono-protected 1,2-diols of unsymmetrical type.Dehydration of these unsymmetrical diols leads to the regioselective formation of methyl ketones.