- Catalytic hydroarylation of alkynes with arenes in the presence of FeCl3 and AgOTf
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Hydroarylation of propiolic acids with various arenes in TFA proceeded efficiently in the presence of FeCl3/AgOTf catalyst system. In the case of electron-rich arenes, the iron-catalyzed hydroarylation gave cinnamic acids in moderate to high yields. The hydroarylation of phenylacetylene was observed but the catalyst was not effective under the same conditions.
- Hashimoto, Takuya,Kutubi, Md. Shahajahan,Izumi, Takayuki,Rahman, Ataur,Kitamura, Tsugio
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experimental part
p. 99 - 105
(2011/02/16)
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- Iron(III)-catalyzed hydroarylation of propiolic acid with activated arenes
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FeCl3/AgOTf-catalyzed hydroarylation of propiolic acid with electron-rich arenes such as mesitylene, tetramethylbenzene, and pentamethylbenzene in trifluoroacetic acid proceeded to give 3-arylpropenoic acids in moderate to high yields. The same reactions with anisole and 1,4-dimethoxybenzene afforded double hydroarylation products, 3,3-diarylpropionic acids.
- Hashimoto, Takuya,Izumi, Takayuki,Kutubi, Md. Shahajahan,Kitamura, Tsugio
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scheme or table
p. 761 - 763
(2010/04/05)
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- Oxidative Coupling of 1-(2,6-Dichlorobenzoyl)pyrroles and -pyrazoles and Alkyl Acrylates by Palladium(II) Acetate
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Treatments of 1-(2,6-dichlorobenzoyl)-, 3-acetyl-1-(2,6-dichlorobenzoyl)-, 1-(2,6-dichlorobenzoyl)-2-formyl-, and 1-(phenylsulfonyl)pyrroles with palladium acetate and alkyl acrylates gave the corresponding α-alkenyl-substituted pyrroles in good yields, while the reaction of 1-(2,6-dichlorobenzoyl)-2,5-dimethylpyrrole gave small amounts of β-alkenyl-substituted pyrroles.Under similar conditions, 1-(2,6-dichlorobenzoyl)pyrazole and 1-(2,6-dichlorobenzoyl)-3,5-dimethylpyrazole reacted with palladium acetate and alkyl acrylates to give the corresponding 4-alkenyl-substituted pyrazoles.The reaction of 1-(2,6-dichlorobenzoyl)-4-methylpyrazole gave 5-alkenyl-substituted pyrazole.
- Itahara, Toshio,Kawasaki, Kazukuni,Ouseto, Fumio
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p. 3488 - 3493
(2007/10/02)
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