133054-21-4 Usage
Description
FMOC-D-THZ-OH is a chemical compound that features a FMOC-protected amino acid linked to a thiazole (THZ) moiety. The FMOC group acts as a protective agent for the amino acid, facilitating selective deprotection and subsequent modification of the amino acid. The thiazole component endows the compound with unique chemical and biological characteristics, which may enable it to engage in diverse reactions and interactions. FMOC-D-THZ-OH holds potential for applications in organic synthesis, chemical biology, and medicinal chemistry, although its specific properties and activities require further investigation through experimental and analytical methods.
Uses
Used in Organic Synthesis:
FMOC-D-THZ-OH is used as a building block for the synthesis of complex organic molecules, leveraging its FMOC-protected amino acid and thiazole moiety to create novel chemical entities.
Used in Chemical Biology:
FMOC-D-THZ-OH is used as a probe or tool in chemical biology to study the interactions between biomolecules and small organic molecules, potentially revealing new insights into biological processes and mechanisms.
Used in Medicinal Chemistry:
FMOC-D-THZ-OH is used as a lead compound in the development of new pharmaceuticals, with its unique structure offering potential therapeutic benefits that can be optimized through further chemical modifications.
Used in the Pharmaceutical Industry:
FMOC-D-THZ-OH is used as a precursor in the synthesis of drug candidates, taking advantage of its reactivity and the versatility of the FMOC protecting group to produce a range of bioactive compounds.
Used in the Chemical Research Industry:
FMOC-D-THZ-OH is used as a research chemical to explore new reaction pathways and mechanisms, contributing to the advancement of chemical knowledge and the discovery of innovative synthetic methods.
Check Digit Verification of cas no
The CAS Registry Mumber 133054-21-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,0,5 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 133054-21:
(8*1)+(7*3)+(6*3)+(5*0)+(4*5)+(3*4)+(2*2)+(1*1)=84
84 % 10 = 4
So 133054-21-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H17NO4S/c21-18(22)17-10-25-11-20(17)19(23)24-9-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16-17H,9-11H2,(H,21,22)/t17-/m0/s1
133054-21-4Relevant articles and documents
Identification of Protein Thiazolidination as a Novel Molecular Signature for Oxidative Stress and Formaldehyde Exposure
Liu, Jingjing,Chan, K. K. Jason,Chan, Wan
, p. 1865 - 1871 (2016)
Chemical modifications of proteins have been well-documented to play important roles in normal cell physiology such as cell signaling and protein functions. They have also been demonstrated to be one of the milestones in the pathophysiology of many human diseases such as cancer, age-related pathology, and neurodegenerative disorders. Here, we report the initial identification of a novel protein modification, cysteine thiazolidination, through reaction with endogenous and exogenous formaldehyde with cysteine residues in proteins. Using an isotope-dilution liquid chromatography-tandem mass spectrometric (LC-MS3) method, we initiated the study by quantitating thioproline in formaldehyde-treated Escherichia coli (E. coli) protein. The study was then extended to quantitate thioproline in protein obtained from formaldehyde- and oxidant-exposed E. coli. Furthermore, N6-formyllysine, a well-defined formylation product between formaldehyde and lysine, was exploited in a comparative study to evaluate the relative reactivity and amount of cysteine thiazolidination in the reaction of formaldehyde with proteins. It is anticipated that cysteine thiazolidination may serve as a novel biomarker for oxidative stress and formaldehyde exposure.
