146982-27-6Relevant articles and documents
A procedure for the large scale preparation of N(ε)-Alloc-lysine and N(ε)-Alloc-N(α)-Fmoc-lysine
Crivici,Lajoie
, p. 49 - 53 (1993)
This report describes a convenient procedure for a 100 g scale preparation of Fmoc-Lys(Alloc) in 85% yield. This method can be easily adapted to a near one-pot procedure with slightly reduced yields. Without requiring the isolation of the intermediate Lys(Alloc).
New effector conjugates, process for their production and their pharmaceutical use
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Page/Page column 15, (2008/06/13)
Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of conjugates for treating proliferative or angiogenesis-associated processes is described.