105047-45-8

Basic information

• Product Name: FMOC-LYS-OH
• Synonyms: FMOC-LYS-OH;FMOC-L-LYS-OH;FMOC-L-LYSINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-LYSINE;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-LYSINE;N-ALPHA-FMOC-L-LYSINE;(S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-6-aminohexanoic acid;Fmoc-Lys
• CAS NO: 105047-45-8
• Molecular Formula: C₂₁H₂₄N₂O₄
• Molecular Weight: 368.43
• Product Categories: Amino Acids;Lysine [Lys, K];Fmoc-Amino Acids and Derivatives
• Mol File: 105047-45-8.mol
• Article Data: 44

Chemical Properties

• Melting Point: 26.8 °C
• Boiling Point: 607.6 °C at 760 mmHg
• Flash Point: 321.3 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 1.29E-15mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Store at 0°C
• PKA: 3.81±0.21(Predicted)
• CAS DataBase Reference: FMOC-LYS-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-LYS-OH(105047-45-8)
• EPA Substance Registry System: FMOC-LYS-OH(105047-45-8)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 105047-45-8(Hazardous Substances Data)

Usage

Description

FMOC-LYS-OH, also known as Nα-Fmoc-L-lysine, is an N-Fmoc-protected form of L-Lysine, an essential amino acid for humans. It is characterized by its white to off-white powder appearance and plays a crucial role in various biological processes due to its importance in protein synthesis.

Uses

Used in Pharmaceutical Industry:
FMOC-LYS-OH is used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason]. Its role in protein synthesis and its protective N-Fmoc group make it a valuable component in the development of new drugs and therapies.
Used in Nutritional Supplements:
FMOC-LYS-OH is used as a supplement for [application reason], providing the essential amino acid L-Lysine to support human health. L-Lysine is important for various bodily functions, including the production of collagen, hormones, and enzymes.
Used in Research and Development:
FMOC-LYS-OH is used as a research compound for [application reason], facilitating the study of protein synthesis, amino acid metabolism, and the development of new therapeutic strategies.
Used in Food Industry:
FMOC-LYS-OH is used as an additive in the food industry for [application reason], enhancing the nutritional value of products and potentially improving the taste and texture of certain foods.
Used in Cosmetics:
FMOC-LYS-OH is used as an ingredient in the cosmetics industry for [application reason], such as promoting skin health and providing anti-aging benefits due to its role in collagen production.

InChI:InChI=1/C21H24N2O4/c22-12-6-5-11-19(20(24)25)23-21(26)27-13-18-16-9-3-1-7-14(16)15-8-2-4-10-17(15)18/h1-4,7-10,18-19H,5-6,11-13,22H2,(H,23,26)(H,24,25)/t19-/m0/s1

Upstream product

• 86060-82-4 Fmoc-Lys(Z)-OH 
• 50-00-0 formaldehyd 
• 1225187-14-3 C₂HF₃O₂*C₃₇H₄₀N₄O₅ 
• 1225187-10-9 C₂HF₃O₂*C₃₆H₃₈N₄O₅ 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 170943-16-5 methyl (((9H-fluoren-9-yl)methoxy)carbonyl)-L-lysinate 
• 172846-56-9 methyl N²-(((9H-fluoren-9-yl)methoxy)carbonyl)-N⁶-(tert-butoxycarbonyl)-L-lysinate 
• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 
• 849752-40-5 2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester 
• 133970-31-7 Fmoc-Lys(ClZ)-OH 
• 159857-60-0 Fmoc-Lys(Mmt)-OH 
• 940941-43-5 Nα-fluorenylmethyloxycarbonyl-L-lysine-tert-butyl ester 
• 56-87-1 L-lysine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 110990-09-5 N^α-(fluoren-9-ylmethoxycarbonyl)-N^ε-biotinyllysine 
• 131602-53-4 amyloid β-protein fragment 25-35 

Relevant articles and documents

Application of tert-Butyl Disulfide-Protected Amino Acids for the Fmoc Solid-Phase Synthesis of Lactam Cyclic Peptides under Mild Metal-Free Conditions

Lactam cyclic peptides are a class of interesting and pharmaceutically active molecules, but their previous syntheses have required the use of heavy metals and/or forcing conditions. Here, we describe the efficient application of the previously reported tert-butyl disulfide-protected amino acids and their use in the efficient, solid-phase synthesis of a series of lactam cyclic peptides under mild, metal-free conditions.

The impact of metal coordination on the assembly of bis(indolyl)methane-naphthalene-diimide amphiphiles

The self-assembly and coordination of amphiphiles comprised of naphthalenediimide (NDI) and bis(indolyl)methane (BIM) chromophores were investigated as a function of pH and metal. As observed by TEM, SEM and AFM imaging, the self-assembly of NDI-BIM 1 pro

Microwave-assisted synthesis of: Meso-carboxyalkyl-BODIPYs and an application to fluorescence imaging

In this study, a significantly improved method for the synthesis of modular meso-BODIPY (boron dipyrromethene) derivatives possessing a free carboxylic acid group (which was subsequently coupled to peptides), is disclosed. This method provides a vastly efficient synthetic route with a > threefold higher overall yield than other reports. The resultant meso-BODIPY acid allowed for further easy incorporation into peptides. The meso-BODIPY peptides showed absorption maxima from 495-498 nm and emission maxima from 504-506 nm, molar absorptivity coefficients from 33383-80434 M-1 cm-1 and fluorescent quantum yields from 0.508-0.849. The meso-BODIPY-c(RGDyK) peptide was evaluated for plasma stability and (proved to be durable even up to 4 h) was then assessed for its fluorescence imaging applicability in vivo and ex vivo. The optical imaging in vivo was limited due to autofluorescence, however, the ex vivo tissue analysis displayed BODIPY-c(RGDyK) internalization and cancer detection thereby making it a novel tumor-integrin associated fluorescent probe while displaying the lack of interference the dye has on the properties of this ligand to bind the receptor. This journal is