153815-60-2

Basic information

• Product Name: FMOC-L-TRYPTOPHANOL
• Synonyms: (S)-(9H-fluoren-9-yl)methyl 1-hydroxy-3-(1H-indol-3-yl)propan-2-ylcarbamate;REF DUPL: Fmoc-Tryptophanol;[(1S)-2-Hydroxy-1-(1H-Indol-3-Ylmethyl)Ethyl]-Carbamic Acid 9H-Fluoren-9-Ylmethyl Ester;Fmoc-L-Trp-ol;Fmoc-L-tryptophanol≥ 99% (HPLC);FMOC-L-TRYPTOPHANOL;FMOC-(S)-2-AMINO-3-(3-INDOLYL)-1-PROPANOL;FMOC-TRP-OL
• CAS NO: 153815-60-2
• Molecular Formula: C₂₆H₂₄N₂O₃
• Molecular Weight: 412.48
• Product Categories: Amino Alcohols;Fmoc-Amino acid series;Amino Acids
• Mol File: 153815-60-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 86-90 °C
• Boiling Point: 697.7±55.0 °C(Predicted)
• Appearance: /
• Density: 1.294±0.06 g/cm3(Predicted)
• Storage Temp.: Store at 0°C
• PKA: 11.43±0.46(Predicted)
• CAS DataBase Reference: FMOC-L-TRYPTOPHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-L-TRYPTOPHANOL(153815-60-2)
• EPA Substance Registry System: FMOC-L-TRYPTOPHANOL(153815-60-2)

Safety Data

• Hazardous Substances Data: 153815-60-2(Hazardous Substances Data)

Usage

Description

FMOC-L-TRYPTOPHANOL, also known as Fmoc-Trp-OH, is a derivative of the essential amino acid Tryptophan, commonly used in the field of biochemistry, particularly in peptide synthesis. It is recognized for its role in the procedure known as Fluorenylmethyloxycarbonyl (Fmoc) protection, used to prevent side reactions during the synthesis process. FMOC-L-TRYPTOPHANOL is designed for laboratory use and is often used in drugs and pharmaceuticals. It has a complex structure, including a benzyl alcohol group and is characterized by its light sensitivity. As such, it requires careful handling and storage, typically in cool and dark conditions, to maintain its stability and effectiveness.

Uses

Used in Biochemistry Research:
FMOC-L-TRYPTOPHANOL is used as a reagent for peptide synthesis, facilitating the Fmoc protection method to prevent side reactions during the synthesis process.
Used in Pharmaceutical Development:
FMOC-L-TRYPTOPHANOL is used as a building block in the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and therapeutics.
Used in Laboratory Settings:
FMOC-L-TRYPTOPHANOL is used as a research tool in laboratories, where its light sensitivity and complex structure are carefully managed to ensure its effectiveness in experiments and analyses.

Upstream product

• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 154-09-6 L-tryptophanol 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 

Downstream Products

• 886991-16-8 C₄₀H₆₁N₃O₅SSi 
• 851707-51-2 tert-butyl (S)-3-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropyl)-1H-indole-1-carboxylate 

Relevant articles and documents

Design, synthesis, and immunochemical characterization of a chimeric glycopeptide corresponding to the Shigella flexneri Y O-polysaccharide and its peptide mimic MDWNMHAA

Two glycopeptide chimeras corresponding to the Shigella flexneri Y O-polysaccharide and its peptide mimic were designed in an attempt to improve the binding affinity by increasing the entropy of binding relative to the original octapeptide mimic of the O-

Synthesis of Chiral N-Protected β-Amino Alcohols by the Use of UNCAs

A facile synthesis of a wide variety of N-protected β-amino alcohol derivatives under mild conditions is described.N-urethane protected amino acid N-carboxyanhydrides (UNCAs) were used as starting material and reduced into the corresponding alcohols with