17083-23-7Relevant articles and documents
Conventional Synthesis of Thymopoietin 32-36 (TP 5) Using the 1-(1-Adamantyl)-1-methyletoxycarbonyl Group
Heinzel, Wolfgang,Kronbach, Thomas,Voelter, Wolfgang
, p. 1652 - 1658 (2007/10/02)
A synthesis of high yields of TP 5 is described.The α-amino functions were blocked by the acid-labile 1-(1-adamantyl)-1-methylethoxycarbonyl-(Adpoc)group.The Adpoc group is cleaved under mild acidolytic conditions with 3percent TFA in CH2Cl2 while the tert-butyl residues remained intact.This selective cleavage of the Adpoc group compared with the Boc and tert-butyl residues allows new strategies for the synthesis of large peptides. - Keywords: Adpoc, Amino acids, Thymopoietin