- Gould-Jacobs Reaction
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Gould-Jacobs Reaction
R. G. Gould, W. A. Jacobs, J. Am. Chem. Soc. 61, 2890 (1939).
Synthesis of 4-hydroxys from anilines and diethyl ethoxymalonate via cyclization of the intermediate anilinomethylenemalonate followed by hydrolysis and decarboxylation:
R. H. Reitsema, Chem. Rev. 43, 53 (1948); R. C. Elderfield, Heterocyclic Compounds 4, 38 (1952); C. C. Price, R. N. Roberts, Org. Syn. coll. vol. III, 272 (New York, 1955); D. G. Markees, L. S. Schwab, Helv. Chim. Acta 55, 1319 (1972); R. Albrecht, G. A. Hoyer, Ber. 105, 3118 (1972); J. M. Barker et al., J. Chem. Res. (S) 1980, 4; A. Pipaud et al., Synth. Commun. 27, 1727 (1997); C. G. Dave, R. D. Shah, Heterocycles 51, 1819 (1999). Cf. Doebner-Miller Reaction; Knorr Quinoline Synthesis.
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