CAS No.13127-18-9,ERYTHROMYCIN OXIME Suppliers

Products Categories

Pharmaceutical (57)
Organic Chemicals (26)
Others (12)
Materials (3)
Reagent (2)
Plant Extract (1)

Basic Information

Molecular Structure:
CAS No.:	13127-18-9
Name:	ERYTHROMYCIN OXIME
Article Data:	13

Formula:	C₃₇H₆₈N₂O₁₃
Molecular Weight:	748.953
Synonyms:	9-Hydroxyiminoerythromycin;Erythromycin 9-ketoxime;Erythromycin A 9-oxime;Erythromycin A oxime;Erythromycin oxime;RU 28111;Erythromycin, 9-oxime;
EINECS:	204-040-1
Density:	1.28 g/cm³
Melting Point:	159-161?C
Boiling Point:	841 °C at 760 mmHg
Flash Point:	462.4 °C
Appearance:	white to slightly yellow powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	209.43000
LogP:	2.04670

Synthetic route

: 114-07-8
erythromycin

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

Conditions

Conditions	Yield
With hydroxylamine; acetic acid In isopropyl alcohol at 50℃; for 24h;	95%
With hydroxylamine hydrochloride; triethylamine In methanol Reflux;	93%
With hydroxylamine hydrochloride; potassium carbonate In methanol at 20℃; for 48h; Solvent; Reagent/catalyst; Temperature;	88.2%

: 114-07-8
erythromycin

A: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

B: 105882-69-7
8,9-anhydropseudoerythromycin A 6,9-hemiketal

Conditions

Conditions	Yield
With hydroxylamine hydrochloride; sodium acetate In methanol at 50℃; for 13h;

: 7704-67-8
erythromycin A thiocyanate

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

Conditions

Conditions	Yield
With hydroxylamine hydrochloride In dichloromethane at 20℃; for 1.5h; pH=7; Beckmann Rearrangement;
With hydroxylamine hydrochloride; ammonium bicarbonate; sodium iodide In methanol at 56 - 60℃; Reagent/catalyst;	89 g

: 1357466-70-6
erythromycin A oxime thiocyanate

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

Conditions

Conditions	Yield
With sodium hydroxide In dichloromethane; water at 38℃; Solvent; Temperature;

: 116-11-0
2-Methoxypropene

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

: 999-97-3
1,1,1,3,3,3-hexamethyl-disilazane

: 119685-40-4
C44H84N2O14Si

Conditions

Conditions	Yield
Stage #1: 2-Methoxypropene; (9-E)-deoxo-9-hydroximinoerythromycin A With Pyridine hydrobromide In dichloromethane at 7 - 17℃; for 2h; Stage #2: 1,1,1,3,3,3-hexamethyl-disilazane In dichloromethane for 1h; Stage #3: With sodium hydrogencarbonate In dichloromethane; water at 27 - 33℃; for 0.5h; Product distribution / selectivity;	96.9%

...Expand

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

: 342371-84-0
9-deoxo-6-deoxy-6,9-epoxy-9,9a-didehydro-9a-aza-homoerythromycin A

Conditions

Conditions	Yield
With sodium hydrogencarbonate; p-toluenesulfonyl chloride In water; acetone at 0 - 20℃; for 4h;	91.8%
With sodium hydrogencarbonate; p-toluenesulfonyl chloride In dichloromethane; water at 0 - 5℃; Product distribution / selectivity;
With sodium hydrogencarbonate; p-toluenesulfonyl chloride In dichloromethane at 20℃; for 1.5h;
With sodium hydrogencarbonate; methanesulfonyl chloride In water at 5℃; Temperature; Reagent/catalyst; Beckmann Rearrangement;

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

: 26116-56-3
erythromycylamine

Conditions

Conditions	Yield
With methanol; sodium tetrahydroborate at 20℃; for 8h; Reagent/catalyst; Temperature; Cooling with ice;	85.03%

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

: 76801-85-9
9-Deoxo-9a-aza-9a-homoerythromycin A

Conditions

Conditions	Yield
Stage #1: (9-E)-deoxo-9-hydroximinoerythromycin A With calcium(II) bis(trifluoromethanesulfonyl)imide; tert-butylammonium hexafluorophosphate(V) In 1,2-dimethoxyethane; 1,2-dichloro-ethane at 80℃; for 5h; Stage #2: With sodium tetrahydroborate In methanol at 0 - 20℃; for 51h;	78%
Multi-step reaction with 2 steps 1: p-toluenesulfonyl chloride; sodium hydrogencarbonate / acetone; water / 4 h / 0 - 20 °C 2: sodium tetrahydroborate; methanol / 24 h / 0 - 20 °C View Scheme

: 1132-95-2
1,1-diisopropoxycyclohexane

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

: 129288-91-1
9-{O-[1-(1-methylethoxy)-cyclohexyl]oxime}-erythromycin

Conditions

Conditions	Yield
With pyridine hydrochloride In dichloromethane at 20℃; for 42h;	71%

: 15761-38-3
L-N-Boc-Ala

: 13127-18-9
(9-E)-deoxo-9-hydroximinoerythromycin A

: C45H81N3O16

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;	70%

Total:86 Page 1 of 3 1 2 3 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 13127-18-9

Chemistry

Empirical Formula of Erythromycin, 9-oxime (CAS NO.13127-18-9): C₃₇H₆₈N₂O₁₃
Molecular Weight: 748.9414
Nominal Mass: 748 Da
Average Mass: 748.9414 Da
Monoisotopic Mass: 748.47214 Da
Index of Refraction: 1.552
Molar Refractivity: 185.92 cm³
Molar Volume: 581.1 cm³
Surface Tension: 41.3 dyne/cm
Density: 1.28 g/cm³
Flash Point: 462.4 °C
Enthalpy of Vaporization: 139 kJ/mol
Boiling Point: 841 °C at 760 mmHg
Vapour Pressure: 7.27E-33 mmHg at 25 °C
Structure of Erythromycin, 9-oxime (CAS NO.13127-18-9):

IUPAC Name: (2R,3S,4S,5R,6R,8R,9E,10S,11R,12S,13R)-5-[(2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-6,11,12-trihydroxy-9-hydroxyimino-3-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-2,4,6,8,10,12-hexamethyl-14-oxacyclotetradecan-1-one
Canonical SMILES: CCC1C(C(C(C(=NO)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)O)(C)O
Isomeric SMILES: CC[C@@H]1[C@@]([C@@H]([C@H](/C(=N/O)/[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)O)(C)O
InChI: InChI=1S/C37H68N2O13/c1-14-25-37(10,45)30(41)20(4)27(38-46)18(2)16-35(8,44)32(52-34-28(40)24(39(11)12)15-19(3)48-34)21(5)29(22(6)33(43)50-25)51-26-17-36(9,47-13)31(42)23(7)49-26/h18-26,28-32,34,40-42,44-46H,14-17H2,1-13H3/b38-27+/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChIKey: KYTWXIARANQMCA-ZTILBQITSA-N

Safety Profile

Hazard Codes of Erythromycin, 9-oxime (CAS NO.13127-18-9): Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.

Specification

Erythromycin, 9-oxime , its cas register number is 13127-18-9. It also can be called Erythromycin-9-oxime ; and Erythromycin oxime .