- Prepartion of Ethyl imidazole-4-carboxylate
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Ethyl -4-carboxylate (CAS NO.: ), with other name of -4-carboxylic acid ethyl ester, could be produced through many synthetic methods.
Following is one of the reaction routes:
The hydrolysis of diethyl imidazole-4,5-dicarboxylate (I) with aqueous NaOH gives imidazole-4,5-dicarboxylic acid (II), which is partially decarboxylated by treatment with refluxing aniline yielding 4-anilinocarbonylimidazole (III). The hydrolysis of (III) with refluxing aqueous HCl affords (IV), which is finally esterified with ethanol and dry HCl at reflux temperature.
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