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Chlorfenvinfos

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Chlorfenvinfos

EINECS 207-432-0
CAS No. 470-90-6 Density 1.373 g/cm3
PSA 54.57000 LogP 5.72830
Solubility insoluble in water Melting Point -23 to -19oC
Formula C12H14Cl3O4P Boiling Point 396.5 °C at 760 mmHg
Molecular Weight 359.574 Flash Point 298.9 °C
Transport Information UN 2810 Appearance Amber-colored liquid with a mild chemical odor
Safety 28-36/37-45-60-61 Risk Codes 24-28-50/53
Molecular Structure Molecular Structure of 470-90-6 (Chlorfenvinfos) Hazard Symbols VeryT+DangerousN
Synonyms

Benzylalcohol, 2,4-dichloro-a-(chloromethylene)-, diethyl phosphate (6CI);Phosphoric acid,2-chloro-1-(2,4-dichlorophenyl)vinyl diethyl ester (8CI);2,4-Dichloro-a-(chloromethylene)benzyldiethylphosphate;2-Chloro-1-(2,4-dichlorophenyl)vinyl diethyl phosphate;Birlan;Birlane;Birlane 10G;CVP;CVP (pesticide);Chlorfenvinfos;Chlorfenvinphos;Chlorphenvinfos;Chlorphenvinphos;Clofenvinfos;Compound 4072;Defiance S;Dermaton;Diethyl 1-(2,4-dichlorophenyl)-2-chlorovinyl phosphate;Diethyl2-chloro-1-(2,4-dichlorophenyl)vinyl phosphate;ENT 24969;Enolofos;GC 4072;Haptasol;O,O-Diethyl O-[1-(2,4-dichlorophenyl)-2-chlorovinyl] phosphate;O,O-Diethyl O-[2-chloro-1-(2,4-dichlorophenyl)vinyl] phosphate;OMS 1328;Quirlan;SD 7859;Sapecron;Sapecron 50EC;Supona;Tarene;Unitox;Vinyphate;Zaprawa enolofos;

Article Data 8

Chlorfenvinfos Consensus Reports

EPA Extremely Hazardous Substances List.

Chlorfenvinfos Specification

The Chlorfenvinphos, with the CAS registry number 470-90-6 and EINECS registry number 207-432-0, has the systematic name of 2-Chloro-1-(2,4-dichlorophenyl)vinyl diethyl phosphate. And the molecular formula of this chemical is C12H14Cl3O4P. It belongs to the following product categories: Acaricides Alphabetic; C; CHPesticides; Insecticides; Oeko-Tex Standard 100; Organophorous Method Specific; Pesticides; Pesticides & Metabolites; Acaricides Pesticides & Metabolites; Alpha sort; CAlphabetic.

The Chlorfenvinphos is an amber-colored liquid with a mild chemical odor. It is an organophosphorus cholinesterase inhibitor that is used as an insecticide and an acaricide, but has been banned in several countries. What's more, it will liberate toxic phosphoric oxide and chloride gas if it is heated.

The physical properties of Chlorfenvinphos are as following: (1)ACD/LogP: 4.51; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 4; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 7; (6)Polar Surface Area: 54.57 Å2; (7)Index of Refraction: 1.534; (8)Molar Refractivity: 81.43 cm3; (9)Molar Volume: 261.8 cm3; (10)Polarizability: 32.28×10-24cm3; (11)Surface Tension: 43.2 dyne/cm; (12)Density: 1.373 g/cm3; (13)Flash Point: 298.9 °C; (14)Enthalpy of Vaporization: 62.15 kJ/mol; (15)Boiling Point: 396.5 °C at 760 mmHg; (16)Vapour Pressure: 3.9E-06 mmHg at 25°C.

You should be cautious while dealing with this chemical. It is toxic in contact with skin, and very toxic if swallowed. It is also very toxic to aquatic organisms, and may cause long-term adverse effects in the aquatic environment. Therefore, you had better take the following instructions: Wear suitable protective clothing and gloves, and in case of accident or if you feel unwell, seek medical advice immediately (show label where possible); After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer); This material and/or its container must be disposed of as hazardous waste; Avoid release to the environment. Refer to special instructions safety data sheet.

You can still convert the following datas into molecular structure:
(1)SMILES: P(OC(\c1c(cc(Cl)cc1)Cl)=C\Cl)(OCC)(OCC)=O
(2)InChI: InChI=1/C12H14Cl3O4P/c1-3-17-20(16,18-4-2)19-12(8-13)10-6-5-9(14)7-11(10)15/h5-8H,3-4H2,1-2H3/b12-8- 

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 13mg/kg (13mg/kg)   Journal de Toxicologie Clinique et Experimentale. Vol. 6(3), Pg. 175, 1986.
cattle LD50 oral 20mg/kg (20mg/kg)   Veterinary Record. Vol. 77, Pg. 1140, 1965.
chicken LD50 intraperitoneal 23100ug/kg (23.1mg/kg)   Veterinary Record. Vol. 77, Pg. 1140, 1965.
chicken LD50 oral 29100ug/kg (29.1mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Toxicology and Applied Pharmacology. Vol. 11, Pg. 49, 1967.
dog LD50 intravenous 51mg/kg (51mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 17, Pg. 323, 1970.
dog LD50 oral 1200mg/kg (1200mg/kg)   "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971Vol. -, Pg. 18, 1971.
domestic animals - goat/sheep LD50 oral 71250ug/kg (71.25mg/kg)   Veterinary Record. Vol. 77, Pg. 1140, 1965.
guinea pig LD50 oral 125mg/kg (125mg/kg)   Biochemical Pharmacology. Vol. 16, Pg. 949, 1967.
human TDLo skin 10mg/kg (10mg/kg) BLOOD: OTHER CHANGES Industrial Medicine and Surgery. Vol. 38, Pg. 25, 1969.
mammal (species unspecified) LD50 oral 10mg/kg (10mg/kg)   Herba Polonica. Vol. 21, Pg. 53, 1975.
mouse LD50 intraperitoneal 87mg/kg (87mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 19, Pg. 612, 1967.
mouse LD50 intravenous 87mg/kg (87mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 19, Pg. 612, 1967.
mouse LD50 oral 65mg/kg (65mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 78, 1967.
mouse LD50 skin 336mg/kg (336mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 1, Pg. 78, 1967.
mouse LD50 subcutaneous 339mg/kg (339mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 19, Pg. 612, 1967.
pigeon LD50 oral 13300ug/kg (13.3mg/kg)   ASTM Special Technical Publication. Vol. (680), Pg. 157, 1979.
quail LD50 oral 148mg/kg (148mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Pesticide Science. Vol. 2, Pg. 148, 1971.
rabbit LD50 oral 300mg/kg (300mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 17, Pg. 323, 1970.
rabbit LD50 skin 400mg/kg (400mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toxicology and Applied Pharmacology. Vol. 17, Pg. 323, 1970.
rat LC50 inhalation 50mg/m3/4H (50mg/m3)   Pesticide Manual. Vol. 9, Pg. 142, 1991.
rat LD50 intraperitoneal 8500ug/kg (8.5mg/kg)   Veterinary Record. Vol. 77, Pg. 1140, 1965.
rat LD50 intravenous 6600ug/kg (6.6mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Toxicology and Applied Pharmacology. Vol. 17, Pg. 323, 1970.
rat LD50 oral 10mg/kg (10mg/kg)   Farm Chemicals Handbook. Vol. -, Pg. C69, 1991.
rat LD50 skin 26400ug/kg (26.4mg/kg)   Acta Physiologica Polonica. Vol. 32, Pg. 507, 1981.
rat LD50 subcutaneous 7mg/kg (7mg/kg)   Acta Physiologica Polonica. Vol. 32, Pg. 507, 1981.

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