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Cas Database |
| Name |
D(+)-Bupivacaine |
EINECS | N/A |
| CAS No. | 27262-45-9 | Density | 1.032 g/cm3 |
| PSA | 32.34000 | LogP | 3.90740 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C18H28 N2 O | Boiling Point | 423.4 ºC |
| Molecular Weight | 288.433 | Flash Point | 209.9ºC |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by subcutaneous, intratracheal and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See other bupicaine or bupivacaine entries. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, (R)-; 2',6'-Pipecoloxylidide, 1-butyl-, (+)-(8CI); (+)-(R)-Bupivacaine; (+)-Bupivacaine; (R)-(+)-Bupivacaine;(R)-Bupivacaine; D-(+)-Bupivacaine; d-Bupivacaine |
Article Data | 14 |
D(+)-Bupivacaine Chemical Properties
Product Name: D(+)-Bupivacaine (CAS NO.27262-45-9)
Molecular Formula: C18H28N2O
Molecular Weight: 288.43g/mol
Mol File: 27262-45-9.mol
Boiling point: 423.4 °C at 760 mmHg
Flash Point: 209.9 °C
Density: 1.032 g/cm3
Surface Tension: 41.5 dyne/cm
Enthalpy of Vaporization: 67.78 kJ/mol
Vapour Pressure: 2.24E-07 mmHg at 25°C
XLogP3-AA: 3.4
H-Bond Donor: 1
H-Bond Acceptor: 2
Structure Descriptors of D(+)-Bupivacaine (CAS NO.27262-45-9):
IUPAC Name: (2R)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
Canonical SMILES: CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
Isomeric SMILES: CCCCN1CCCC[C@@H]1C(=O)NC2=C(C=CC=C2C)C
InChI: InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)/t16-/m1/s1
InChIKey: LEBVLXFERQHONN-MRXNPFEDSA-N
D(+)-Bupivacaine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 7900ug/kg (7.9mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972. | |
| mouse | LD50 | subcutaneous | 30mg/kg (30mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972. | |
| rabbit | LD50 | intratracheal | 10mg/kg (10mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976. | |
| rabbit | LD50 | parenteral | > 120mg/kg (120mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 78, 1976. | |
| rabbit | LDLo | intravenous | 5500ug/kg (5.5mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972. |
| rat | LD50 | intravenous | 3800ug/kg (3.8mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972. | |
| rat | LD50 | subcutaneous | 38mg/kg (38mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 31, Pg. 273, 1972. |
D(+)-Bupivacaine Safety Profile
Poison by subcutaneous, intratracheal and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See other bupicaine or bupivacaine entries.
D(+)-Bupivacaine Specification
D(+)-Bupivacaine ,its CAS NO. is 27262-45-9,the synonyms is 2',6'-Pipecoloxylidide, 1-butyl-, D-(+)- .
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