|Name:||Morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-methyl- (5a,6a)-, diacetate (ester), hydrochloride|
|Formula:||C21H23 N O5 . Cl H|
|Synonyms:||Morphinan-3,6a-diol, 7,8-didehydro-4,5a-epoxy-17-methyl-, diacetate(ester), hydrochloride (8CI); (-)-Heroin hydrochloride; Diacetylmorphinehydrochloride; Diamorphine hydrochloride; Heroin hydrochloride; NSC 302357|
|Safety:||x and HCl. See also HEROIN and (−)-MORPHINE."> Poison by intraperitoneal and intravenous routes. An experimental teratogen. A narcotic. Addictive. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also HEROIN and (−)-MORPHINE.|
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Chemical Name: Diacetylmorphine hydrochloride ci (25 mg) (as) (heroin hydrochloride)
CAS No.: 1502-95-0
Molecular Formula: C21H24ClNO5
Molecular Weight: 405.87 g/mol
Flash Point: 251.9 °C
Boiling Point: 492.9 °C at 760 mmHg
Storage temp.: -20°C
Following is the structure of Diacetylmorphine hydrochloride (CAS No.:1502-95-0):
The chemical synonymous of Diacetylmorphine hydrochloride (CAS No.:1502-95-0) are Diacetylmorphine hydrochloride ci (25 mg) (as) (heroin hydrochloride) ; Heroinehydrochloride ; o,o'-Diacetylmorphine hydrochloride ; Heroin hydrochloride solution
Diacetylmorphine hydrochloride (CAS No.:1502-95-0) was first synthesized in 1874 by C. R. Alder Wright, an English chemist working at St. Mary's Hospital Medical School in London. He had been experimenting with combining morphine with various acids. He boiled anhydrous morphine alkaloid with acetic anhydride for several hours and produced a more potent, acetylated form of morphine, now called diacetylmorphine. The compound was sent to F. M. Pierce of Owens College in Manchester for analysis.
|Organism||Test Type||Route||Reported Dose (Normalized Dose)||Effect||Source|
|mouse||LD||subcutaneous||> 60mg/kg (60mg/kg)||Archives Internationales de Pharmacodynamie et de Therapie. Vol. 221, Pg. 266, 1976.|
|mouse||LD50||intraperitoneal||240mg/kg (240mg/kg)||Archives Internationales de Pharmacodynamie et de Therapie. Vol. 122, Pg. 434, 1959.|
|mouse||LD50||intravenous||38mg/kg (38mg/kg)||Toxicology and Applied Pharmacology. Vol. 6, Pg. 334, 1964.|
Poison by intraperitoneal and intravenous routes. An experimental teratogen. A narcotic. Addictive. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also HEROIN and (−)-MORPHINE.
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25
Safety Statements 16-36/37-45
Hazard Codes: T F
Risk Statements about Diacetylmorphine hydrochloride (CAS No.:1502-95-0):
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements about Diacetylmorphine hydrochloride (CAS No.:1502-95-0):
S16:Keep away from sources of ignition.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.
Diacetylmorphine hydrochloride (CAS No.:1502-95-0) is a semi-synthetic opioid drug synthesized from morphine, a derivative of the opium poppy. It is the 3,6-diacetyl ester of morphine (di (two)-acetyl-morphine). The white crystalline form is commonly the hydrochloride salt diacetylmorphine hydrochloride, though often adulterated thus dulling the sheen and consistency from that to a matte white powder, which however heroin freebase typically is.As with other opioids, heroin is used as both a pain-killer and a recreational drug and has an extremely high potential for abuse. Frequent and regular administration is associated with tolerance, moderate physical dependence, and severe psychological dependence which develops into addiction.Internationally,it is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs.It is illegal to manufacture, possess, or sell diacetylmorphine without a licence in Belgium, Denmark, Germany, Iran, India, the Netherlands, the United States, Australia, Canada, Ireland, Pakistan, the United Kingdom and Swaziland.Under the name diamorphine, it is a legally prescribed controlled drug in the United Kingdom. It is available for prescription to long-term users in the Netherlands, the United Kingdom, Switzerland, Germany and Denmark alongside psycho-social care.The opium poppy was cultivated in lower Mesopotamia as long ago as 3400 BC.The chemical analysis of opium in the 19th century revealed that most of its activity could be ascribed to two alkaloids, codeine and morphine.