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Diacetylmorphine hydrochloride

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Name Diacetylmorphine hydrochloride EINECS
CAS No. 1502-95-0 Density g/cm3
Solubility Melting Point
Formula C21H23 N O5 . Cl H Boiling Point 492.9°Cat760mmHg
Molecular Weight 405.91 Flash Point 251.9°C
Transport Information Appearance
Safety Poison by intraperitoneal and intravenous routes. An experimental teratogen. A narcotic. Addictive. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also HEROIN and (−)-MORPHINE. Risk Codes 11-23/24/25-39/23/24/25
Molecular Structure Molecular Structure of 1502-95-0 (Morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-methyl- (5a,6a)-, diacetate (ester), hydrochloride) Hazard Symbols
Synonyms

Morphinan-3,6a-diol, 7,8-didehydro-4,5a-epoxy-17-methyl-, diacetate(ester), hydrochloride (8CI); (-)-Heroin hydrochloride; Diacetylmorphinehydrochloride; Diamorphine hydrochloride; Heroin hydrochloride; NSC 302357

 

Chemistry

Chemical Name: Diacetylmorphine hydrochloride ci (25 mg) (as) (heroin hydrochloride)
CAS No.: 1502-95-0
EINECS: 216-124-5
Molecular Formula: C21H24ClNO5
Molecular Weight: 405.87 g/mol
Flash Point: 251.9 °C
Boiling Point: 492.9 °C at 760 mmHg
Storage temp.: -20°C
Following is the structure of Diacetylmorphine hydrochloride (CAS No.:1502-95-0):


The chemical synonymous of Diacetylmorphine hydrochloride (CAS No.:1502-95-0) are Diacetylmorphine hydrochloride ci (25 mg) (as) (heroin hydrochloride) ; Heroinehydrochloride ; o,o'-Diacetylmorphine hydrochloride ; Heroin hydrochloride solution

History

Diacetylmorphine hydrochloride (CAS No.:1502-95-0) was first synthesized in 1874 by C. R. Alder Wright, an English chemist working at St. Mary's Hospital Medical School in London. He had been experimenting with combining morphine with various acids. He boiled anhydrous morphine alkaloid with acetic anhydride for several hours and produced a more potent, acetylated form of morphine, now called diacetylmorphine. The compound was sent to F. M. Pierce of Owens College in Manchester for analysis.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD subcutaneous > 60mg/kg (60mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 221, Pg. 266, 1976.
mouse LD50 intraperitoneal 240mg/kg (240mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 122, Pg. 434, 1959.
mouse LD50 intravenous 38mg/kg (38mg/kg)   Toxicology and Applied Pharmacology. Vol. 6, Pg. 334, 1964.

Safety Profile

Poison by intraperitoneal and intravenous routes. An experimental teratogen. A narcotic. Addictive. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also HEROIN and (−)-MORPHINE.
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25
Safety Statements 16-36/37-45

Hazard Codes: ToxicFlammableF
Risk Statements about Diacetylmorphine hydrochloride (CAS No.:1502-95-0):
R11:Highly flammable. 
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
Safety Statements about Diacetylmorphine hydrochloride (CAS No.:1502-95-0):
S16:Keep away from sources of ignition. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37:Wear suitable protective clothing and gloves.

Specification

Diacetylmorphine hydrochloride (CAS No.:1502-95-0) is a semi-synthetic opioid drug synthesized from morphine, a derivative of the opium poppy. It is the 3,6-diacetyl ester of morphine (di (two)-acetyl-morphine). The white crystalline form is commonly the hydrochloride salt diacetylmorphine hydrochloride, though often adulterated thus dulling the sheen and consistency from that to a matte white powder, which however heroin freebase typically is.As with other opioids, heroin is used as both a pain-killer and a recreational drug and has an extremely high potential for abuse. Frequent and regular administration is associated with tolerance, moderate physical dependence, and severe psychological dependence which develops into addiction.Internationally,it is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs.It is illegal to manufacture, possess, or sell diacetylmorphine without a licence in Belgium, Denmark, Germany, Iran, India, the Netherlands, the United States, Australia, Canada, Ireland, Pakistan, the United Kingdom and Swaziland.Under the name diamorphine, it is a legally prescribed controlled drug in the United Kingdom. It is available for prescription to long-term users in the Netherlands, the United Kingdom, Switzerland, Germany and Denmark alongside psycho-social care.The opium poppy was cultivated in lower Mesopotamia as long ago as 3400 BC.The chemical analysis of opium in the 19th century revealed that most of its activity could be ascribed to two alkaloids, codeine and morphine.

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