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Dichloromethylenediphosphonic acid disodium salt

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  • Name Dichloromethylenediphosphonic acid disodium salt
  • EINECS245-078-9
  • CAS No. 22560-50-5
  • Density2.306g/cm3
  • PSA140.34000
  • LogP1.30710
  • SolubilityN/A
  • Melting Point>330 °C
  • FormulaCH2Cl2Na2O6P2
  • Boiling Point474.7oC at 760mmHg
  • Molecular Weight332.82
  • Flash Point240.9oC
  • Transport InformationN/A
  • AppearanceWhite solid
  • Safety
  • Risk CodesN/A
  • Molecular Structure
    Molecular Structure of 22560-50-5 (Dichloromethylenediphosphonic acid disodium salt)
  • Hazard SymbolsN/A
  • SynonymsN/A

Dichloromethylenediphosphonic acid disodium salt Chemical Properties

IUPAC Name: disodium [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate (22560-50-5)
Synonyms:  Clodronic acid disodium salt
Molecular Structure : 
Molecular Formula : CH2Cl2Na2O6P2
Molecular Weight : 288.86
CAS:  22560-50-5
EINECS:  245-078-9
Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
Mol File: 22560-50-5.mol
Melting point: >330°C 

Dichloromethylenediphosphonic acid disodium salt Uses

Sodium clodronate (22560-50-5) is used for Hypercalcaemia (too much calcium in the blood) ,some types of bone pain .

Dichloromethylenediphosphonic acid disodium salt Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 780mg/kg (780mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 intravenous 75mg/kg (75mg/kg)   British UK Patent Application. Vol. #2096889,
mouse LD50 oral > 2gm/kg (2000mg/kg)   British UK Patent Application. Vol. #2096889,

Dichloromethylenediphosphonic acid disodium salt Safety Profile

WGK Germany : 3
RTECS:  SZ7640700

Dichloromethylenediphosphonic acid disodium salt Specification

1.Sodium clodronate (22560-50-5) works by binding to bone and reducing the rate at which bone is broken down. 
2.When bone is broken down, calcium is lost from the bone and seeps into the blood. In cancer, there is excessive breakdown of bone which leads to high levels of calcium in the blood. As sodium clodronate prevents bone from being broken down as quickly, it reduces these high levels of calcium in the blood that are a result of cancer.
3.Store Sodium clodronate (22560-50-5) in a cool, dry place, away from direct heat and light

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