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IUPAC Name: disodium [dichloro-[hydroxy(oxido)phosphoryl]methyl]-hydroxyphosphinate (22560-50-5)
Synonyms: Clodronic acid disodium salt
Molecular Structure :
Molecular Formula : CH2Cl2Na2O6P2
Molecular Weight : 288.86
CAS: 22560-50-5
EINECS: 245-078-9
Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents
Mol File: 22560-50-5.mol
Melting point: >330°C
Sodium clodronate (22560-50-5) is used for Hypercalcaemia (too much calcium in the blood) ,some types of bone pain .
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 780mg/kg (780mg/kg) | British UK Patent Application. Vol. #2096889, | |
mouse | LD50 | intravenous | 75mg/kg (75mg/kg) | British UK Patent Application. Vol. #2096889, | |
mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | British UK Patent Application. Vol. #2096889, |
WGK Germany : 3
RTECS: SZ7640700
1.Sodium clodronate (22560-50-5) works by binding to bone and reducing the rate at which bone is broken down.
2.When bone is broken down, calcium is lost from the bone and seeps into the blood. In cancer, there is excessive breakdown of bone which leads to high levels of calcium in the blood. As sodium clodronate prevents bone from being broken down as quickly, it reduces these high levels of calcium in the blood that are a result of cancer.
3.Store Sodium clodronate (22560-50-5) in a cool, dry place, away from direct heat and light