Journal of Coordination Chemistry p. 1959 - 1973 (2013)
Update date:2022-08-16
Topics:
Gul, Rukhsana
Khan, Azim
Badshah, Amin
Rauf, Muhammad Khawar
Shah, Afzal
-Rehman, Zia-Ur
Bano, Asghari
Naz, Rabia
Tahir, Muhammad Nawaz
Six new ferrocenyl phenylguanidines have been synthesized and characterized by elemental analysis, FT-IR, multinuclear (1H and 13C) NMR, and single crystal analysis. The latter showed a supramolecular structure for 2 mediated by O H and π H interactions. A subsequent DNA-binding study of these complexes proved them to be good DNA binders with the binding constant varying in the range of 1.2-5.6×105M-1. These compounds were found to have moderate antibacterial and significant antifungal activities, especially for compounds having a chlorophenyl. These compounds may emerge as a new class of anticancer and antifungal agents alone or in combination with other drugs.
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(1954)